甲肝减毒活疫苗纳入广东省扩大免疫规划项目成本-效益分析  

Expanding Immunization Project by Bringing Attenuated Hepatitis A Vaccine into Guangdong Province

作　　者：张吉凯 郑慧贞[2] 梁剑[2] 夏艳辉 

机构地区：[1]广东省生物制品与药物研究所,广州510440 [2]广东省疾病预防控制中心,广州511430

出　　处：《中国卫生经济》2013年第7期62-65,共4页Chinese Health Economics

基　　金：广东省医学科研基金(A2009071)

摘　　要：目的:科学评估甲肝减毒活疫苗纳入广东省扩大免疫规划项目所产生的经济效益。方法:先采用加权平均法确定社会贴现率,再采用净现值法计算净效益和成本效益比,进行成本-效益分析最后采用逐项替代的敏感性分析方法定量评估参数变化对净效益和成本效益比的影响。结果:广东省2010年将甲肝减毒活疫苗纳入免疫规划,投入成本4 155.56万元,可以减少甲肝病例72 417人,即每投入573.84元,就可以减少1例甲肝病例。在疫苗保护期内,社会贴现率为3.38%,累计产生净效益约2.92亿元,效益成本比为8.02∶1。敏感性分析结果显示所有参数在最小值与最大值之间变动后,净效益在0.94～14.62亿元之间变动,效益成本比在3.27～36.18之间变动。结论:甲肝减毒活疫苗纳入广东省扩大免疫规划项目这一公共卫生项目具有稳健的经济效益和较高的投资回报,实现了政府资源的有效配置。Objective： To evaluate the economic benefit of the expanding immunization project by bringing the attenuated hepatitis vaccine into Guangdong Province. Methods： Use weighted average method to ensure the discount rate, and use net present value metho to calculate net benefit （NB） and benefit-cost ratio （BCR）, then the impact of parameter change on NB and BCR was applied b： sensitivity analysis method for each alternative quantitative assessment. Results： In 2010, an investment of RMB 4 155 560 000 ot bringing attenuated hepatitis A vaccine into the expanded program on immunization of Guangdong Province, it could reduce 72 41 cases of hepatitis A, which means RMB 573.84 per input can reduce 1 case of hepatitis A. During the protecting period of vaccine, th, social discount rate was 3.38%, and the net economic benefit was about RMB 292 million produced by the program and the BCR wa 8.02：1. The resuh of sensitivity analysis shows NB change between RMB 94 million and 1.462 billion and BCR changes between RMI 327 milion and 3.618 billion while all parameter varies between the maximum and the minimum. Conclusion： Bringing attenuate hepatitis A vaccine into Guangdong Province has brought healthy economic benefits and a higher investment return which achieves the, effective allocation of government resources.

关 键 词：甲肝减毒活疫苗 扩大免疫规划 成本-效益分析 

分 类 号：R186[医药卫生—流行病学]