单剂量右美托咪啶对七氟烷吸入麻醉苏醒期躁动的影响  

Effects of dexmedetomidine on agitation in recovery period after sevoflurane anesthesia

作　　者：鲁会卿[1] 李宏[1] 陈宁[1] 

机构地区：[1]武警后勤学院附属医院麻醉科,天津300162

出　　处：《山西医科大学学报》2013年第7期573-575,共3页Journal of Shanxi Medical University

摘　　要：目的观察右美托咪啶用于七氟烷吸入全身麻醉时对苏醒期躁动的影响。方法选择60例ASAⅠ-Ⅱ级择期上腹部手术的患者60例,采用随机数字法根据随机双盲原则分为实验组和对照组,两组患者均应用瑞芬太尼复合七氟烷进行麻醉维持,于手术结束前30 min实验组右美托咪啶0.5μg/kg稀释至10 ml微量输注泵输注、对照组对照组给予相同容积的生理盐水,10 min泵完。患者送入麻醉恢复室自然苏醒,由同一经过培训的恢复室医生记录不同时点血流动力学指标及镇静-躁动评分。结果对照组苏醒期拔管期间平均动脉压、心率波动明显,实验组较为平稳,差异有统计学意义;两组间苏醒期躁动发生率比较,差异也有统计学意义(均P<0.05)。结论单次给予0.5μg/kg右美托咪啶增加七氟烷全麻苏醒期心血管稳定性,降低躁动的发生率。Objective To explore the effects of dexmedetomidine on emergence agitation after sevoflurane anesthesia. Methods Sixty ASAⅠ-Ⅱ patients undergoing elective abdominal operation under sevoflurane anesthesia were randomized into 2 groups（n=30）.All patients received infusion of remifentanil and inhalation of 2%-3% sevoflurane.The patients were given intravenously 0.5 μg/kg dexmedetomidine in dexmedetomidine group 30 min before the end of surgery and 0.9% NaCl in control group.The same observer in postanesthesia care unit（PACU） was blinded to treatment groups.Hemodynamic parameters and emergence agitation was evaluated at different time points. Results Heart rate and mean arterial pressure were significantly lower in dexmedetomidine group than in control group（P0.05）.The incidence of agitation was also significantly lower in dexmedetomidine group than in control group（P0.05）. Conclusion Single dose of 0.5 μg/kg dexmedetomidine can promote the hemodynamic stability during extubation and reduce the incidence of agitation in recovery period after sevoflurane anesthesia.

关 键 词：右美托咪啶 七氟烷 苏醒期 躁动 

分 类 号：R614.2[医药卫生—麻醉学]