肝脏转氨酶与空腹血糖受损和2型糖尿病的关系研究  

Study on the relationship between impaired fasting glucose and type 2 diabetes mellitus with serum aminotransferase activities

作　　者：赵立芸[1,2] 李雪[1] 冯任南[1] 孔庆滨[2] 李颖[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院营养与食品卫生教研室,黑龙江哈尔滨150081 [2]东北林业大学校医院,黑龙江哈尔滨150040

出　　处：《中华疾病控制杂志》2013年第1期1-4,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81172649);国家863重点项目(2010AA023002);黑龙江省科技攻关项目(GC10C205)

摘　　要：目的探讨人群中肝脏转氨酶与空腹血糖受损(impaired fasting glucose,IFG)和2型糖尿病(type 2diabetes mellitus,T2DM)的关系。方法通过对2 402名18～75岁成年人进行体格检查,检测血清谷丙转氨酶(al-anine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、谷氨酰转肽酶(gamma-glu-tamyltransferase,GGT)、血糖、血脂等血清学指标。对ALT、AST、GGT从低到高按四分位间距分组(Q1到Q4),分析3种转氨酶与IFG、T2DM之间的关系。结果 ALT、AST、GGT各自四分位分组中,Q4组与Q1组相比,空腹血糖,年龄、体质指数(body mass index,BMI)、收缩压、舒张压、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白指标间差异均有统计学意义(均有P<0.05)。多元Logistic回归分析表明,在校正了BMI、吸烟、饮酒、咖啡的因素之后,ALT、GGT是IFG和T2DM独立的危险因素,与Q1相比,Q4组ALT与IFG、T2DM的OR值分别为:1.74(1.30～2.34),1.47(1.09～2.41);Q4组GGT与IFG、T2DM的OR值分别为:3.15(2.01～4.45),4.08(1.88～7.65)。结论高水平的血清ALT、GGT与多种代谢异常密切相关,两者是IFG、T2DM患病的危险因素。Objective To investigate the relationships between impaired fasting glucose （IFG） and type 2 diabe- tes mellitus （T2DM） with the elevated serum aminotransferase activities. Methods The association between IFG and T2DM with serum aminotransferase activities was examined by detecting serum alanine aminotransferase （ALT）, gamma- glutamyltransferase （ GGT）, and aspartate aminotransferase （AST）. 2 402 adults aged from 18 to 75 were selected to con- duct physical examinations and questionnaire surveys. Then the values of serum aminotransferases were divided into four groups according to interquartiles range to analyze the associations of these 3 aminotransferases with IFG and T2DM. Re- sults Compared with Q1, fasting blood glucose （FBG）, age, body mass index （BMI）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, total cholesterol （TC）, and triglyeeride （TG） etc. in Q4 increased significantly. After adjusting BMI, alcohol use, smoking, and coffee consumption, ALT and GGT were risk factors of IFG and T2DM inde- pendently detected by Logistic regression. Compared with Q1, the adjusted odds ratios （ORs） of the elevated ALT and IFG for T2DM in Q4 were 1.74（ 1.30-2. 34）, 1.47（ 1.09-2. 41 ）, respectively and the ORs of the elevated GGT for IFG and T2DM in Q4 were 3. 15 （2.01-4. 45 ） and 4. 08 （ 1.88-7.65 ）, respectively. Conclusions Elevated ALT and GGT levels are positively associated with metabolic abnormalities. ALT and GGT are independent risk factors for IFG and T2DM.

关 键 词：血糖 糖尿病 2型 天冬氨酸氨基转移酶类 

分 类 号：R587.1[医药卫生—内分泌]