医学纳米材料毒理学研究进展  

Progress in research on toxicology of nanomaterials used in nanomedicine

作　　者：刘魁[1] 岳霞[1] 赵进顺[1] 

机构地区：[1]宁波大学医学院预防医学系,浙江宁波315211

出　　处：《中华疾病控制杂志》2013年第1期72-76,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81273111);宁波市自然科学基金(2012A610185)

摘　　要：随着纳米技术的发展,纳米材料由于其独特的理化特性已经在医学领域被广泛应用。纳米材料用于医学领域有诸多特性:第一,纳米材料具有细微的粒径和较大的比表面积;第二,纳米材料通过静脉和皮下注射的途径进入人体后可以与体内的生物大分子相互作用。但以上的特性也可能产生不利影响。本文总结了常见纳米材料的毒理学研究进展并为这些知识在纳米医学中的应用提供依据。Due to the development of nanotechnology, nanomaterials have been widely used in the field of medi- cine. Owning to its unique physical and chemical characteristics, the application of nanomaterials to the medical field will have many advantages. Firstly, nanomaterials have subtle particle size and enormous surface area. Secondly, in the appli- cation of the nanomaterials, it usually enter the human body by way of intravenous and subcutaneous injection, these parti- cles can interact with biological macromoleeules in the human body easily. The most important thing is that insoluble nanop- articles may be gathered in the specific tissues and organs of the human body. However, these characteristics may also be adversely affected. This review summarizes the progress of toxicology studies of the common nanomaterials and provides ba- sis for the application of this knowledge in nanomedieine.

关 键 词：纳米结构 发病率 毒理学 

分 类 号：R994.6[医药卫生—毒理学]