甘氨双唑钠及其一个微量成分的质谱研究  

STUDY ON MASS SPECTRA OF SODIUM GLYCIDAZOLE AND IT'S A MICRO COMPONENT

作　　者：王志蓓[1] 徐永珍[1] 吴厚铭[1] 高建国[2] 郑秀龙[2] 丁旭刚[2] 

机构地区：[1]中国科学院上海有机化学研究所 [2]第二军医大学放射医学研究室

出　　处：《质谱学报》2000年第3期125-126,共2页Journal of Chinese Mass Spectrometry Society

摘　　要：The synthesis of sodium glycidazole yields three products detected by HPLC. Electrospray ionization mass spectrometry has been successfully applied to identify the three products. ESI mass spectrometry demonstrated that the first component is 2-nitro-5-emthylimidazole as impurity and the third component is the target compound, sodium glycidazole, as main product. The second and the third components were further investigated by the scanning of the daughter ion at m/z 373[M+H]+, m/z 520[M+H]+ using ESI tandem mass spectrometry. The experimental results show that the second component has the structure similar to the desired product but without one imidazolering.The synthesis of sodium glycidazole yields three products detected by HPLC. Electrospray ionization mass spectrometry has been successfully applied to identify the three products. ESI mass spectrometry demonstrated that the first component is 2-nitro-5-emthylimidazole as impurity and the third component is the target compound, sodium glycidazole, as main product. The second and the third components were further investigated by the scanning of the daughter ion at m/z 373[M+H]+, m/z 520[M+H]+ using ESI tandem mass spectrometry. The experimental results show that the second component has the structure similar to the desired product but without one imidazolering.

关 键 词：甘氨双唑钠 肿瘤放疗药 微量成分分析 质谱法 

分 类 号：R979.19[医药卫生—药品] R927[医药卫生—药学]