N-1-取代苯并三唑的简易快速合成及生物活性  

A NOVEL SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-1-SUBSTITUTED BENZOTRIAZOLES

作　　者：谢筱娟[1] 杨高升[1] 程林[1] 

机构地区：[1]安徽师范大学化学系,安徽芜湖241000

出　　处：《化学研究与应用》2000年第5期498-502,共5页Chemical Research and Application

基　　金：安徽省教委基金

摘　　要：本文应用相转移催化和微波辐射合成 1 0个 N-1 -取代苯并三唑 ;N-1 -苄基、-乙氧羰基亚甲基、-芳基、-乙酰基、2个一羧亚甲氧烷基苯并三唑及 4个二 (苯并三唑基 )烷烃 ,其中有 7个为新化合物 ,这种简易快速方法具有产率高、反应时间短、操作方便、低能耗和无环境污染的优点。初步测试它们的生物活性 ,大多数化合物具有较好的抗菌活性。Ten compounds N 1 Substituted benzotriazoles (N 1 benzyl ethoxycarbonylmethylene, aryl, acetyl,two carboxymethyleneoxyalkyl benzotriazoles and four bi(benzotriazol 1 yl) alkane) were synthesized using phase transfer catalyst and microware radiation.There were seven new compounds in these compounds.A novel methods have advantages of good yield,short reaction time,convenient,low energy consume and environnent friendly.Some compounds were found to have moderatel antibacterial actirities.

关 键 词：N-1-取代苯并三唑 合成 相转移催化 微波 

分 类 号：O626.26[理学—有机化学] O621.29[理学—化学]