血、尿β_2微球蛋白与糖尿病肾病中医证型相关性研究  

Study on the correlation between β_2-microglobulin in serum and urinary and diabetic nephropathy CM syndromes

作　　者：莫伟[1] 周晖[1] 张芸[1] 龙文醒[1] 江丹[1] 杨晓珍[1] 李玉玲[1] 曹明满[1] 

机构地区：[1]广东省第二中医院,广东广州510095

出　　处：《湖南中医药大学学报》2013年第7期82-85,共4页Journal of Hunan University of Chinese Medicine

基　　金：广东省科技厅科研项目(2010B030700057);广东省中医药局科研项目(2010266)

摘　　要：目的探讨血、尿β2微球蛋白水平在糖尿病肾病中医各证型分布规律。方法采用回顾调查分析法收集187例糖尿病肾病患者,按阴虚燥热、气阴两虚、脾肾气虚、阴阳两虚分为4组,观察比较各组血、尿β2微球蛋白、血肌酐水平。结果 1.证型分布:阴虚燥热组27例(14.4%),气阴两虚组60例(32.1%),脾肾气虚组59例(31.6%),阴阳两虚组41例(21.9%);2.血、尿β2微球蛋白水平在糖尿病肾病各证型中按阴虚燥热、气阴两虚、脾肾气虚、阴阳两虚呈逐步增高的趋势。3.血、尿β2微球蛋白水平在糖尿病肾病中医各证型的差异有显著统计学意义(P<0.01)。血β2微球蛋白水平组间两两比较显示,气阴两虚组与阴虚燥热组比较,差异有统计学意义(P<0.05),其余各组间比较,差异均有显著统计学意义(P<0.01);对尿β2微球蛋白水平组间两两比较显示,气阴两虚组与阴虚燥热组及脾肾气虚组比较,差异均有统计学意义(P<0.05);其余各组间比较差异有显著统计学意义(P<0.01)。肌酐水平仅在阴阳两虚组与各组比较有显著统计学意义(P<0.01),在其余各组间比较差异无统计学意义。结论糖尿病肾病随着中医证型的演变,肾功能出现逐步恶化,中医证型与血、尿β2微球蛋白水平具有一定相关性,可用于辅助诊断中医证型。Objective To investigate β2-microglobulin in serum and urinary distribution laws in diabetic nephropathy CM syndromes.Methods 187 diabetic nephropathy patients were selected for retrospective survey analysis.Patients were divided into 4 groups as Yin deficiency and heat group,Qi and Yin deficiency group,spleen and kidney Qi deficiency group and Yin and Yang deficiency group.β2-microglobulin levels in serum and urinary and serum creatinine level were tested and compared between 2 groups.Results 1.Syndromes distribution law was shown as： Yin deficiency and heat group had 27 cases（14.4%）,Qi and Yin deficiency group had 60 cases（32.1%）,spleen and kidney Qi deficiency group had 59 cases（31.6%）,Yin and Yang deficiency group had 41 cases（21.9%）.2.β2-microglobulin in serum and urinary levels increased significantly in different degrees in 4 groups.3.The differences of β2-microglobulin levels in serum and urinary in 4 groups were statistically significant（P0.01）.Comparisons of serum β2-microglobulin levels showed that the difference between Qi and Yin deficiency group and Yin deficiency and heat group was statistically significant（P〈0.05） and the differences among other groups also were significant（P 0.01）.Comparisons of urinary β 2-microglobulin levels showed that the difference between Qi and Yin deficiency group,Yin deficiency and heat group and spleen and kidney Qi deficiency group was statistically significant（P〈0.05） and the differences among other groups were also significant（P 0.01）.Comparisons of serum creatinine levels showed that the differences between Yin and Yang deficiency group and other groups were statistically significant（P〈0.05） but the differences among other groups had no statistical significance.Conclusion As CM syndromes of diabetic nephropathy were evolving,renal function gradually deteriorated.The CM syndrome has some relevance with serum and urinary β 2-microglobulin levels,which can help syndrome diagnosis.

关 键 词：糖尿病肾病 中医证型 血Β2微球蛋白 尿Β2微球蛋白 

分 类 号：R587.2[医药卫生—内分泌]