新三羟基—西松烯二萜内酯  

A New Trihydroxylated Cembrenolide Diterpene

作　　者：杨若林[1] 曾陇梅[1] 苏镜娱[1] 李红 

机构地区：[1]中山大学化学系,广州510275

出　　处：《化学学报》2000年第10期1186-1187,共2页Acta Chimica Sinica

基　　金：国家自然科学基金(29932030);广东省自然科学基金(960012)

摘　　要：西松烯型二萜是存在于多种植物、昆虫及海洋生物中的一类十四元环二萜,迄今仅从海洋生物中发现的这类化合物就已超过三百多种,其中不少具有生物活性.我们从采自海南三亚的条状短指软珊瑚(sinularia capillosa)中分离得四个西松烯二萜内酯(1～4).化合物(1)是新的三羟基西松烯内酯,通过波谱方法测定了它的结构.Four cembrenolides (1 - 4) were isolated from the soft coral sinularia capillosa collected around Sanya,Hainan Island, China. Compound (1) ,C20H32O5 ,m.p. 158 - 160℃,[α]D25 +42.8°(c 0.05,EtOH) is a new compound. Its structure was elucidated on the basis of spectroscopic data. The relative stereochemistry of 1 was determined to be 1R* ,4R* ,5S* , 12S* , 13R* mainly by NOESY and NOE difference spectra. Compound (4),flexibilide,exhibited potent cytotoxicity toward HepA and EAC cell lines.

关 键 词：软珊瑚 西松烯内酯 细胞毒活性 结构 

分 类 号：O629[理学—有机化学]