镝促进下醛、酮与炔丙基溴及苯基炔丙基溴的高选择性反应  

Highly Selective Reaction of Propargyl Bromide with Carbonyl Compounds Promoted by Metal Dysprosium

作　　者：李志铭[1] 贾瑜[1] 周景尧[1] 

机构地区：[1]复旦大学化学系,上海200433

出　　处：《化学学报》2000年第10期1301-1306,共6页Acta Chimica Sinica

基　　金：国家自然科学基金(29872008)

摘　　要：在金属镝的促进下,醛、酮可与炔丙基溴反应,高选择性高产率地得到相应的高炔丙醇,没有发现连二烯醇的存在.当用苯基炔丙基溴代替炔丙基溴与醛、酮反应时,主要得到了相应的连二烯醇,而没有发现高快丙醇的存在,由此提出了六元环过渡态的反应机理.Promoted by metal dysprosium, aldehydes and ketones could react smoothly with propargyl bromide to afford the corresponding homopropargylic alcohols in good to excellent yields, and no allenic alcohols were found. However, carbonyl compounds only afford the corresponding allenic alcohols when propargyl bromide was replaced by 1 - phenyl - 3 - bromopropargyl bromide, and no homopargylic alcohols were formed.

关 键 词：镝 炔丙基化反应 高炔丙醇 连二烯醇 醛 酮 

分 类 号：O621.25[理学—有机化学]