具有磁效应的温敏性药物载体的制备及表征  

Preparation and Characterization of the Magnetic and Thermo-responsive Drug Carrier

作　　者：贾梦虹 任杰[1] 任天斌[1] 

机构地区：[1]同济大学材料科学与工程学院纳米与生物高分子材料研究所,上海200092

出　　处：《高分子通报》2013年第7期50-55,共6页Polymer Bulletin

摘　　要：在合成具备一定分子结构的聚(N-异丙基丙烯酰胺)-聚乳酸(PNIPAAm-PLA)嵌段共聚物的基础上,采用透析法制备了PNIPAAm-PLA共聚物磁性复合胶束和囊泡。本文发现不同的制备工艺条件会分别形成胶束和囊泡两种载体形态,并对两种载体的形貌进行了细致对比,发现两种结构特点的载体分别适合疏水性和亲水性药物的装载。对复合胶束的最低临界溶解温度(LCST)进行了表征研究,得到其LCST在38℃左右,略高于人体体温。对不同Fe4O3磁性粒子投料比对应制备的复合胶束的磁性能进行了较详细的测试,发现磁性粒子的加入量对其磁响应性影响不大。In the study, A certain molecular structure of the PNIPAAm-PLA block copolymer is synthesized. Dialysis is applied to prepare the PNIPAAm-PLA magnetic composite micelles and vesicles. Different preparation conditions form micelles and vesicles respectively, and the morphology of the two carrier s is contrasted. Two structures of the carrier are suitable for the loading of hydrophobic drug and hydrophilic drugs respectively. The LCST of composite micelles is characterized, its LCST is around 38℃ ,which is little higher than normal body temperature. Different feed ratios of Fe4O3 magnetic particles leads to different magnetic properties of micelles, but the ratio doesn＇t play an important role in magnetic property.

关 键 词：磁效应 温敏性 药物载体 

分 类 号：TQ460.4[化学工程—制药化工]