食管癌患者手术前后血清E-cad、SICAM-1和IL-8检测的临床意义  

Clinical Significance of Measurement the Changes on Serum E-cad,SICAM-l and IL-8 Levels in Postoperative Patients with Esophageal Cancer

作　　者：黄正军[1] 

机构地区：[1]江苏省沭阳县中心医院胸外科,223600

出　　处：《放射免疫学杂志》2013年第4期395-396,共2页Journal of Radioimmanology

摘　　要：目的:探讨了食管癌患者手术前后血清E-cad、SICAM-1和IL-8水平的变化及临床意义。方法:应用放射免疫分析和酶联法对33例食管癌患者进行了手术前后血清E-cad、SICAM-1和IL-8检测,并与35名正常健康人作比较。结果:食管癌患者在手术前血清E-cad、SICAM-1和IL-8水平均非常显著地高于正常人组(P<0.01),手术治疗6个月后则与正常人组比较无显著性差异(P>0.05)。血清E-cad水平与SICAM-1、IL-8水平呈正相关(r=0.6188、0.5012,P<0.01)。结论:检测食管癌患者手术前后E-cad、SICAM-1和IL-8水平的变化具有真实的价值。Objective To explore the clinical significance of determining the changes on serum E-cad,SICAM-1 and IL-8 levels after operation in patients with esophageal cancer.Methods Serum IL-8（with RIA） and serum E-cad,ICAM-1（with ELISA） levels were determined in 33 patients with esophageal cancer both before and after operation as well as in 35 normal healthy controls.Results Before operation the serum E-cad,ICAM-1 and IL-8 levels in the patients were significantly higher than those in the controls（P 0.01）.After operation for 6 months serum E-cad,ICAM-1and IL-8 levels showed no more difference from the controls（P 0.05）.Serum E-cad level was positively correlated with ICAM-1,IL-8 levels（r = 0.6188,0.5012,P 0.01）.Conclusion Changes of serum E-cad ICAM-1and IL-8 levels might be of substantial prognostic value in patients with esophageal cancer.

关 键 词：食管癌 上皮钙粘蛋白 可溶性细胞粘附分子-1 白细胞介素-8 

分 类 号：R541.4[医药卫生—心血管疾病]