侵袭性牙周炎患者血清IL-2、IL-10和β-防御素-2检测的临床意义  

Clinical Significance of Measurement the Changes of Serum IL-2,IL-10 and Beta-Defensin-2 Levels in Patients with Aggressive Periodontitis

作　　者：王统伍[1] 

机构地区：[1]江苏省连云港市第一人民医院苍梧分院,222006

出　　处：《放射免疫学杂志》2013年第4期406-407,共2页Journal of Radioimmanology

摘　　要：目的:探讨侵袭性牙周炎患者治疗前后血清IL-2、IL-10和β-防御素-2水平的变化及临床意义。方法:应用放射免疫分析和酶联法对40例侵袭性牙周炎患者进行了治疗前后血清IL-2、IL-10和β-防御素-2检测,并与35名正常健康人作比较。结果:侵袭性牙周炎患者在治疗前IL-2和β-防御素-2的水平均显著地低于正常人组(P<0.01),而IL-10水平又显著地高于正常人组(P<0.01)。经治疗3个月后与正常人组比较仍有显著性差异(P<0.05)。结论:侵袭性牙周炎患者血清IL-2和β-防御素-2水平的降低与IL-10水平的升高可能是侵袭性牙周炎的独立危险因素。Objective To explore the clinical significance of changes on serum IL-2,IL-10 and beta-defensin-2 levels both before and after treatment in patients with aggressive periodontitis.Methods Serum IL-2,IL-10（with RIA） and beta-defensin-2（with ELISA） levels were determined in 40 patients with aggressive periodontitis and 35 normal healthy controls.Results Before treatment,serum IL-2 and beta-defensin-2 levels were significantly lower than those in controls（P 0.01）.But serum IL-10 levels were markedly higher than that of controls（P 0.01）.After treatment for 3 months,the levels changed notably by toward normal,but remained significant difference from the controls（P 0.05）.Conclusion Decreased serum IL-2,beta-defensin-2 and increased IL-10 was found after aggressive periodontitis may be uniquely of risk factor.

关 键 词：侵袭性牙周炎 白细胞介素-2 白细胞介素-10 Β-防御素-2 

分 类 号：R56[医药卫生—呼吸系统]