CHD患者血清PAPP-A、ICAM-1和hs-CRP检测的临床价值  

The Clinical Values of Serum PAPP-A,ICAM-1 and hs-CRP Levels in Patients with Coronary Heart Diseases

作　　者：任军生 姚加平 

机构地区：[1]江苏省连云港灌云仁济医院,222200 [2]江苏省灌云县人民医院,222200

出　　处：《放射免疫学杂志》2013年第4期467-469,共3页Journal of Radioimmanology

摘　　要：目的:探讨冠心病(CHD)患者治疗前后血清妊娠相关蛋白A(PAPP-A)、血管细胞间黏附分子-1(ICAM-1)和超敏C-反应蛋白(hs-CRP)水平的临床应用价值。方法:采用化学放光法、酶联法和免疫比浊法对66例CHD患者进行了治疗前后血清PAPP-A、ICAM-1和hs-CRP检测,其中稳定型心绞痛(SAP)30例,不稳定型心绞痛(UAP)23例,急性心肌梗死(AMI)13例,并以35名正常健康人作比较。结果:CHD患者在治疗前血清PAPP-A、ICAM-1和hs-CRP水平均非常显著地高于正常人组(P<0.01),经中西医结合治疗3个月后则与正常人组比较无显著性差异(P>0.05)。结论:血清PAPP-A、ICAM-1和hs-CRP水平的变化与CHD的发生、发展密切相关。Objective To explore the clinical values of serum PAPP-A,ICAM-1 and hs-CRP levels both before and after treatment in patients with coronary heart diseases.Methods Serum PAPP-A（with CLIA）,serum ICAM-1（with ELISA） and serum hsCRP（with immunoturbidimetry） levels in 66 patients with coronary heart diseases both before and after treatment（30 SAP,23 UAP,13 AMI） and 35 normal healthy controls.Results Before treatment,serum PAPP-A,ICAM-1 and hs-CRP levels showed significantly higher than those in controls（P 0.01）,after treatment for 3 months,those variables expressed about the same as in controls（P 0.05）.Conclusion The serum PAPP-A,ICAM-1 and hs-CRP levels manifested well correlated to the development and progress of coronary heart diseases.

关 键 词：冠心病 妊娠相关蛋白A 血管细胞间粘附分子-1 超敏C-反应蛋白 稳定型心绞痛 不稳定型心绞痛 急性心肌梗死 

分 类 号：R714.2[医药卫生—妇产科学]