肺表面活性物质对支气管肺发育不良婴幼儿的肺功能评价研究  

Assessment of the effect of surfactant on pulmonary function in bronchopulmonary dysplasia infants

作　　者：王焕焕[1] 聂川[2] 黄水清[2] 

机构地区：[1]广州医科大学附属广东省妇儿医院新生儿科,广东广州510000 [2]广东省妇幼保健院

出　　处：《中国妇幼保健》2013年第20期3273-3276,共4页Maternal and Child Health Care of China

基　　金：2011年广东省科技计划项目〔2011B031800364〕

摘　　要：目的:评价肺表面活性物质(Pulmonary surfactant,PS)对支气管肺发育不良(bronchopulmonary dysplasia,BPD)婴幼儿肺功能的影响。方法:胎龄<32周,出生体重<1 500 g,出院时诊断为BPD的早产儿40例,按有无使用PS分为PS组(20例)和非PS组(20例)。动态监测两组患儿1岁、2岁、3岁时的肺功能情况,主要是潮气呼吸参数中的达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、吸气时间(Ti)、呼气时间(Te)、潮气量(VT)、身高、体重、出院后3年中因呼吸系统疾病再入院次数。结果:1岁时PS组与非PS组的肺功能参数值、身高、体重、均无明显差异(P均>0.05)。2岁及3岁时PS组的各项肺功能参数、身高、体重均优于非PS组,(P均<0.05),差异有统计学意义。出院后3年中因患呼吸系统疾病再入院次数的比较中发现,PS组平均住院(2.63±0.80)次,而非PS组为(4.57±1.22)次,差异有统计学意义(P<0.05)。结论:PS替代治疗可以改善BPD患儿2岁及3岁时的生长发育状况、肺功能状况、并降低BPD患儿再入院次数。Objective：To assess the effect of pulmonary surfactant（PS） on pulmonary function in bronchopulmonary dysplasia（BPD） infants.Methods：Forty preterm infants with BPD were enrolled（gestational age less than thirty-two weeks,weighting less than 1 500 g）,and divided into PS and non-PS groups.Pulmonary function was monitored at 1,2,3 years old,including TPTEF/TE,VPEF/VE,Ti,Te,VT.Body height,weight and the times of re-hospitol caused by respiratory disease were detected.Results：At one years old,there were no significant differences between non-PS and PS groups in lung function parameters,height,body weight（P0.05）.At two years old and three years old,all above indicators were better in PS group than those of non-PS group（P0.05）.The number of admited to hospital in PS group was（2.63±0.08） times,however was（4.57±1.22） times in non-PS group,there was significant difference.Conclusion：PS replacement therapy can improve BPD infants of two and three years old the growth condition,pulmonary function,and reduce the number of admissions to hospital.

关 键 词：支气管肺发育不良 婴幼儿 肺功能 潮气呼吸流速容量环 

分 类 号：R722[医药卫生—儿科]