消郁安神胶囊中挥发油β-环糊精包合物的热稳定性考察  

Thermal Stability Investigation of β-Cyclodextrin Inclusion Complex of Volatile Oil from Xiaoyu Anshen Capsules

作　　者：李卿[1] 宋国红[1] 秦伟翰[1] 蒋渝[1] 秦剑 

机构地区：[1]重庆市中药研究院,重庆400065 [2]重庆市食品药品检验所,重庆401121

出　　处：《中国实验方剂学杂志》2013年第14期17-19,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项(2009ZX09103-405)

摘　　要：目的:考察消郁安神胶囊中挥发油β-环糊精包合物的热稳定性。方法:采用GC-MS测定挥发油β-环糊精包合物于不同温度下百秋李醇含量。色谱条件为HP-5毛细管色谱柱(0.25 mm×30 m,0.25μm),Sim模式选择离子模式,检测器电压1.5 kV。结果:挥发油包合物于40,60,80℃加热4 h,百秋李醇含量未发生明显变化。结论:消郁安神胶囊中挥发油β-环糊精包合物热稳定性良好,可用于指导该制剂成型工艺设计。Objective： To observe thermal stability of β-cyclodextrin inclusion complex of volatile oil from Xiaoyu Anshen capsules.Method： The content of patchouli alcohol at different temperatures from β-cyclodextrin inclusion complex of volatile oil was determined by GC-MS.Chromatographic conditions were as follows： HP-5 capillary column（0.25 mm × 30 m,0.25 μm）,took selective ion mode（SIM）,voltage of detector set at 1.5 kV.Result： The content of patchouli alcohol was no significant change after inclusion complex of volatile oil heating 4 h at different temperatures（40,60,80 ℃）.Conclusion： Thermal stability of β-cyclodextrin inclusion complex of volatile oil from Xiaoyu Anshen capsules was good,it could guide molding process of this preparation.

关 键 词：消郁安神胶囊 百秋李醇 Β-环糊精包合物 热稳定性 

分 类 号：R283.6[医药卫生—中药学]