效应面法优化枳术颗粒的提取工艺  

Optimization of Extraction Technology of Zhizhu Granules by Response Surface Methodology

作　　者：龚建平[1] 刘慧莹[2] 饶毅[1] 陈笑天[2] 龚菁[2] 吴东[1] 金浩鑫[1] 

机构地区：[1]中药固体制剂制造技术国家工程研究中心,南昌330006 [2]江西中医学院,南昌330006

出　　处：《中国实验方剂学杂志》2013年第14期19-22,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划课题(2011BAI04B06)

摘　　要：目的:优化枳术颗粒的提取工艺条件。方法:采用Box-Behnken效应面分析法,在单因素试验基础上,以辛弗林提取率为指标,考察加水量、提取时间、提取次数对枳术颗粒提取工艺的影响。结果:最佳提取条件为称取处方量药材,加490 mL水煎煮3次,每次115 min,辛弗林提取率达90.57%。结论:Box-Behnken法适用于枳术颗粒提取工艺的优选,建立的数学模型预测值与实验观察值相符。Objective： To optimize extraction technology of Zhizhu granules.Method： Based on single factor tests,with yield of synephrine as index,effect of water addition,extraction time and times on extraction technology of Zhizhu granules was investigated by Box-Behnken response surface methodology.Result： Optimum extraction technology was as following： took prescription amount of raw materials,reflux extracted 3 times with 490 mL water,115 min each time;Average yield of synephrine was up to 90.57%.Conclusion： Box-Behnken design was suitable for optimizing extraction technology of Zhizhu granules,the observed value approximated to the predicted value of established mathematical model.

关 键 词：枳术颗粒 辛弗林 BOX-BEHNKEN设计 效应面法 

分 类 号：R283.6[医药卫生—中药学]