白屈菜红碱、血根碱单体的分离和鉴定  

Separation and Identification of Chelerythrine and Sanguinarine Monomer

作　　者：冯泓瑞[1] 黄松[1] 陈玲玲[1] 鲁芹飞[1] 林吉[1] 赖小平[1] 

机构地区：[1]广州中医药大学新药研发中心,广州510006

出　　处：《中国实验方剂学杂志》2013年第14期36-38,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划项目(2012BAI29B00)

摘　　要：目的:分离及鉴定白屈菜红碱和血根碱单体。方法:采用柱色谱分离技术对白屈菜红碱和血根碱进行分离纯化,通过HPLC进行鉴定。结果:采用柱色谱法可获得单一成分,经HPLC鉴定为白屈菜红碱和血根碱单体,纯度分别为98.6%,95.7%。结论:采用柱色谱技术可从博落回中提取、分离到高纯度的白屈菜红碱和血根碱单体。Objective： To isolate and identify chelerythrine and sanguinarine monomer. Method： Chelerythrine and sanguinarine were isolated and purified by column chromatography technology, and identified by HPLC. Result： Single component could be obtained by column chromatography method, chelerythrine and the sanguinarine monomer were identified by HPLC with purity of 98.6% , 95.7%, respectively. Conclusion： Column chromatography technology could obtain high purity chelerythrine and sanguinarine monomer from Macleaya cordata.

关 键 词：柱色谱 白屈菜红碱 血根碱 博落回 高效液相色谱法 

分 类 号：R283.6[医药卫生—中药学]