星点设计-效应面法优选克疣纳米乳处方  

Optimization of Formulation of Keyou Nanoemulsion by Central Composite Design-Response Surface Methodology

作　　者：贾永艳[1] 袁玉霞[1] 魏超娟[1] 田效志[1] 祝侠丽[1] 尹香阁[1] 赵文龙[1] 

机构地区：[1]河南中医学院,郑州450046

出　　处：《中国实验方剂学杂志》2013年第14期39-42,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：郑州市科技攻关项目(0910 SGYS33390-2)

摘　　要：目的:优化克疣纳米乳的处方工艺。方法:以外观性状和粒径的综合评分为因变量,混合表面活性剂-肉豆蔻酸异丙酯(IPM),聚山梨酯80-无水乙醇、水-表面活性剂为自变量,采用星点设计-效应面优化法优选克疣纳米乳的处方工艺。结果:最佳处方为混合表面活性剂-IPM(8.090∶1),聚山梨酯80-无水乙醇(3.082∶1),水-表面活性剂(8.606 1∶1)。制备的克疣纳米乳平均粒径27.46 nm,Zeta电位-0.522 4 mV。结论:优化的处方工艺稳定可行,制备的克疣纳米乳质量符合要求。Objective： To optimize prescription of Keyou nanoemulsion.Method： With composite score of appearance and particle size as dependent variable,ratio of mixed surfactant-isopropyl（IPM）,tween 80ethanol and water-surfactant as independent variables,blank prescription of Keyou nanoemulsion was optimized by central composite design-response surface methodology,and then added drug to prepared blank Keyou nanoemulsion.Result： Optimal prescription was as following： mixed surfactant-IPM（8.090 ∶ 1）,tween 80ethanol（3.082∶ 1）,water-surfactant（8.606 1 ∶ 1）.Average particle size of prepared Keyou nanoemulsion was 27.46 nm,Zeta potential value was-0.522 4 mV.Conclusion： This optimized process was stable and feasible for preparation of Keyou nanoemulsion.

关 键 词：克疣纳米乳 星点设计效应面法 粒径 

分 类 号：R283.6[医药卫生—中药学]