复方红花泡腾颗粒的体外透皮吸收性能考察  

Research of in vitro Transdermal Absorption Properties of Compound Safflower Effervescent Granules

作　　者：韩宝龙[1] 薛强强[1] 杜文婷[1] 邓欢欢[1] 耿子颖[1] 杨官娥[1] 

机构地区：[1]山西医科大学药学院,太原030001

出　　处：《中国实验方剂学杂志》2013年第14期45-47,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：太原市科技项目计划大学生创新创业专题(120164092)

摘　　要：目的:考察复方红花泡腾颗粒的体外透皮吸收性能。方法:采用扩散池法进行体外透皮吸收试验,通过UV测定接收液中乌头总碱含量,筛选合适的接收液及接收液温度,考察复方红花泡腾颗粒的经皮给药效果。结果:选取生理盐水为接收液,接收液温度32℃,复方红花泡腾颗粒的透皮吸收效果优于提取液及普通颗粒制剂。结论:复方红花泡腾颗粒制剂具有良好的透皮吸收效果。Objective： To investigate in vitro transdermal absorption properties of compound safflower effervescent granules.Method： In vitro transdermal absorption experiment was performed through diffusion cell method,the content of total alkaloids from Aconitum carmichaeli was determined by UV in order to choose suitable receiving liquid and receiving liquid temperature,then transdermal effect of compound safflower effervescent granules was investigated.Result： Physiological saline was selected as receiving liquid with temperature at 32 ℃,transdermal absorption effect of compound safflower effervescent granules was better than extraction liquid and common granules.Conclusion： Compound safflower effervescent granules had good transdermal absorption effect.

关 键 词：外用制剂 透皮吸收 红花 泡腾颗粒 乌头总碱 

分 类 号：R283.6[医药卫生—中药学]