液固压缩技术速释α-细辛脑的机制探讨  

Investigation of Immediate-Release Mechanism of α-Asarone by Liquisolid Compacts

作　　者：赵许杰[1] 闫雪生[2] 徐新刚[2] 崔兵兵[1] 

机构地区：[1]山东中医药大学,济南250355 [2]山东省中医药研究院,济南250014

出　　处：《中国实验方剂学杂志》2013年第14期56-58,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨液固压缩技术使α-细辛脑快速溶出的机制。方法:以聚山梨酯-80为液体赋形剂,微晶纤维素PH-101为载体材料,微粉硅胶200为涂层材料,制备药液比1∶4的α-细辛脑液固压缩片,比较其与市售普通片的溶出度,通过测定X-射线衍射(XRD)和崩解时限,探讨该压缩片的速释机制。结果:液固压缩片中α-细辛脑在5 min时,溶出度>80%。XRD表明液固压缩片中无α-细辛脑的特征峰。结论:采用液固压缩技术可改善药物润湿性,增加药物溶出时有效表面积,使难溶性药物快速溶出。Objective： To investigate rapid dissolution mechanism of α-asarone by liquisolid compacts.Method： α-Asarone liquisolid tablets were prepared with solid-liquid ratio of 1∶ 4,tween-80 as liquid excipient,microcrystalline cellulose PH-101 as carrier material,aerosil  200 as coating material.Dissolution of these liquisolid tablets and common tablets was compared,rapid release mechanism of these liquisolid tablets was investigated by measuring X-ray diffraction（XRD） and disintegration time.Result： Dissolution of α-asarone in liquisolid tablets was more than 80% in 5 min.XRD showed that there was no characteristic peaks of α-asarone in liquisolid tablets.Conclusion： Liquisolid compacts could improve drugs wetting properties and increase effective surface area of drugs dissolution,then allowing rapid dissolution of poorly soluble drugs.

关 键 词：Α-细辛脑 聚山梨酯-80 液固压缩片 溶出度 X-射线衍射 

分 类 号：R283.6[医药卫生—中药学]