益气化瘀利水方对HIV/AIDS合并糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响  

Effect of Yiqi Huayu Lishui Decoction on Vascular Endothelial Growth Factor and Urinary Albumin Excretion Rate in Patents of Early Diabetic Nephropathy Combined with HIV/AIDS

作　　者：张佩江[1] 郭建中[2] 

机构地区：[1]河南中医学院,郑州450000 [2]河南省中医药研究院附属医院,郑州450004

出　　处：《中国实验方剂学杂志》2013年第14期314-317,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省医学科技攻关计划省部共建项目(2011010016)

摘　　要：目的:探讨益气化瘀利水复方对HIV/AIDS合并糖尿病肾病患者血管内皮生长因子(VEGF)及尿蛋白排泄率(UAER)的影响。方法:56例HIV/AIDS合并糖尿病肾病患者随机按数字排列法分为治疗组和对照组各28例,两组均进行抗病毒、降糖等西药常规治疗,治疗组给益气化瘀利水复方(当归芍药散合防己黄芪汤),口服,1剂/d,疗程3个月。采用酶联免疫吸附试验(ELISA)检测VEGF水平;放射免疫法检测尿白蛋白,计算UAER。结果:治疗组血清VEGF水平较治疗前明显下降(P<0.01),UAER较治疗前明显下降(P<0.01),且治疗组优于对照组(P<0.01)。结论:益气化瘀利水复方可降低HIV/AIDS合并糖尿病肾病患者血清VECG水平,同时降低UAER,是其保护肾功能的可能作用机制之一。Objective： To explore the effect of Yiqi Huayu Lishui decoction（YQHYLSD） on vascular endothelial growth factor（VEGF） and urinary albumin excretion rate（UAER） in patents of early diabetic nephropathy combined with HIV / AIDS.Method： Fifty six cases of early diabetic nephropathy combined with HIV / AIDS were randomly divided into two groups.Two groups were received routine western medicine treatment and antivirus.The treatment group was treated with YQHYLSD one dose daily for 3 months.The levels of plasma VEGF in the two groups were measured by immunohistochemisty and enzyme linked immunosorbent assay.The urinary albumin excretion was measured to calculate UAER.Result： The plasma levels of VEGF and UAER in treatment group were significantly lower then those of control group,and the outcome in treatment group was more effective then that in the control group（P 0.05）.Conclusion： VECG and UAER play an important role in the pathogenesis of early diabetic nephropathy patients combined with HIV / AIDS.YQHYLSD can degrade VEGF and UAER levels of early diabetic nephropathy patients,which is one of possible mechanism of YQHYLSD protecting the renal function.

关 键 词：益气化瘀利水方 HIV AIDS并糖尿病肾病 血管内皮生长因子 尿蛋白排泄率 

分 类 号：R287[医药卫生—中药学]