中药治疗溃疡性结肠炎古今用药统计分析  

Statistical Analysis and Comparison of Ancient and Modern Prescriptions in Treatment of Ulcerative Colitis

作　　者：吴德智[1,2] 管咏梅[2] 张妮[1] 郭慧玲[1] 朱卫丰[2] 杨明[2,3] 刘红宁[2] 

机构地区：[1]成都中医药大学药学院,成都611137 [2]江西中医学院现代中药制剂教育部重点实验室,南昌330004 [3]江西中医学院药学院,南昌330025

出　　处：《中国实验方剂学杂志》2013年第14期320-325,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项"十二五"重大新药创制(2013ZX09103002-001);江西省落地计划项目(赣财教[2011]243号)

摘　　要：目的:通过系统收集分析溃疡性结肠炎(UC)古今用药,归纳古今常用有效药物,分析用药规律和比较用药趋势。方法:收集治疗UC古今方,应用SPSS 11.5统计软件建立数据库,进行频数分析、相关分析、聚类分析、配对样本t检验,归纳用药规律和古今用药差异性。结果:共收集治疗UC古方461首,今方286首。频数分析显示古今治疗UC高频药物分别为甘草、当归、干姜、木香、茯苓和甘草、木香、茯苓、陈皮、厚朴等药物。相关分析表明,多组治疗UC药物间具有显著正相关性,聚类分析进一步指出了UC方中的药物配伍关系,t检验提示古今治疗UC用药趋势具有显著性差异。结论:由统计数据推导得出古方治疗UC以补气血、温脾胃为治疗规律;今方以补益肺脾之气、清热化湿解毒、活血化瘀、行气导滞、健脾胃为治疗规律。古今方在治疗UC用药趋势上有显著性差异。Objective： Through the systematic collection of ancient and modern drugs in treatment of ulcerative colitis to summarize the ancient and modern used effective drugs and analysis of medicine laws including compare drug trends between ancient and modern medicine.Method： The ancient and modern prescriptions were collected and SPSS 11.5 statistics software was applied to establish a database,so as to summarize medicine laws depending on correlation analysis,frequency analysis and cluster analysis as well as difference between ancient and modern medicine made by student t test.Result： A total of 461 the ancient prescription and 286 the modern prescription collected.Licorice,angelica,ginger,wood,poria et al of ancient high-frequency medicine and licorice,woody,poria,dried tangerine peel,Magnolia et al of modern high-frequency were showed by frequency analysis.The significant positive correlation between the medicine were showed by correlation analysis.UC prescription medicine compatibility relations were further pointed out by cluster analysis.A significant difference between ancient and modern UC drug trends was showed by student t tests.Conclusion： The ancient prescriptions are applied to supplement Qi and blood,invigorate spleen and stomach deduced by the statistical data.While,the modern prescriptions are applied to replenish lung and spleen Qi,clear heat and remove dampness detoxification,promote blood circulation and remove blood stasis,harmony Qi and purge stagnation,spleen and stomach,invigorate spleen and stomach.There was significant difference between ancient and modern medicine trends.

关 键 词：溃疡性结肠炎 用药统计 分析与比较 

分 类 号：R287[医药卫生—中药学]