基于中医传承辅助系统分析杨文华教授治疗白血病的用药经验  

Analyzing Professor YANG Wenhua's Herbal Administration Experience for Leukemia Treatment Based on Traditional Chinese Medicine Inheritance Support System

作　　者：杨向东[1] 杨文华[1] 张佳[2] 陈艳鑫[2] 郭江水[1] 

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]武警医学院附属医院,天津300162

出　　处：《中国实验方剂学杂志》2013年第14期340-343,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：天津市教委项目(20100206);天津市自然科学基金项目(12JCQNJC09000)

摘　　要：目的:基于中医传承辅助系统(V1.1)软件,分析杨文华教授治疗化疗间期白血病的用药经验。方法:收集杨文华门诊治疗化疗间期白血病的病案,录入"中医传承辅助系统",采用该软件集成的规则分析、改进的互信息法、复杂系统熵聚类等数据挖掘方法,结合专家本人校审,共同分析药物使用频次、对药配伍、组方特点等。结果:对筛选出的153个处方进行分析,处方中共出现中药142味,确定各种药物的使用频次,药物之间的关联规则,演化得到核心组合18个、新处方8个,杨文华教授确认药物组合及新处方为其治疗化疗间期白血病的核心用药。结论:杨文华教授治疗化疗间期白血病特点突出,用药准确细致,中医传承辅助系统分析结果与专家临床辨证论治心得基本吻合,中医传承辅助系统可用于名老中医临床经验分析与总结。Objective： To analyze Professor YANG Wen-hua＇s herbal administration experience for Leukemia treatment based on traditional Chinese medicine inheritance support system（V1.1）.Method： Collecting the prescriptions used for Leukemia patients treated with chemotherapy,data were logged into the traditional Chinese medicine inheritance support system,by using principle analysis,revised mutual information,complex system entropy cluster and unsupervised hierarchical clustering,together with Professor YANG＇s personal proofreading to analyze the composing principles of prescriptions---the frequency of drugs,coupled drugs and composing characters.Result： One hundred and fifty-three prescriptions were bolted and analyzed,in which 142 kinds of herbs appeared,after checking the frequency of each herb and the relative rules between all kinds of drugs,we got 18 core groups and 8 new prescriptions,and these were conformed as the core herbs for treating Leukemiatreated with chemotherapy by Professor YANG Wenhua herself.Conclusion： Professor YANG Wenhua＇s prescriptions has outstanding characteristics in treating Leukemia and accurate.The consequences were obtained by the traditional Chinese medicine inheritance support system and the professor＇s experience is generally accordant,the system can be used to analyze and summarize the experiences of famous veteran doctors of Traditional Chinese Medicine.

关 键 词：杨文华 化疗间期白血病 用药经验 中医传承辅助系统(V1 1) 

分 类 号：R287[医药卫生—中药学]