蛇床子素体内过程及其组分配伍和药剂学技术应用影响研究  

Research on Disposition of Osthol and Compatibility of its Components and Pharmaceutical Methods Application

作　　者：恽菲[1,2] 狄留庆[1,2] 陈乐天[1] 蔡宝昌[1] 单进军 赵晓莉 康安 

机构地区：[1]南京中医药大学药学院,南京210046 [2]南京市中药微丸产业化工程技术研究中心,南京210046 [3]江苏省中药高效给药系统工程技术研究中心,南京210046

出　　处：《中国实验方剂学杂志》2013年第14期347-350,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：教育部科学技术研究重点项目(208051);江苏省高校"青蓝工程"科技创新团队支持计划[苏教师(2008)30号];江苏省优势学科建设项目(YSXK-2010)

摘　　要：以中药蛇床子亲脂性活性成分蛇床子素为对象,分析了蛇床子素的吸收、分布、代谢、排泄制征等体过程,静脉注射、腹腔注射、口服蛇床子的药物动力学特征及组分配伍及药剂学技术应用对蛇床子素体内过程的影响。结果显示难溶性中药活性成分蛇床子素膜渗透性好,但是生物利用度较低,组分配伍可影响其体内过程,改善其生物利用度。改善和提高中药活性成分生物利用度不仅可以应用药剂学技术,也可体现在中药组分合理配伍之中,对进一步开展剂型设计和生物有效性评价具有极其重要的意义。To analyze effective methods for improving and enhancing the bioavailability of the active ingredients in the traditional Chinese medicine（TCM）.On the basis of summarizing and analyzing the biopharmaceutical and pharmacokinetic characteristics of osthol,the main active ingredient of fructus cnidii,pharmaceutical methods and components compatibility are proposed to have influence on the bioavailability and disposition of osthol.Osthol,as a poorly water soluble drug,had a good permeability,but bioavailability was poor.Pharmaceutical methods and components compatibility are helpful to improve the poor bioavailability of osthol.To improve and enhance the bioavailability of the active ingredients in the TCM,we can not only resort to pharmaceutical methods,but also the reasonable application of components compatibility between the TCM.

关 键 词：蛇床子素 体内过程 生物利用度 组分配伍 药剂学技术 

分 类 号：R285.5[医药卫生—中药学] R383.6[医药卫生—中医学]