维生素C阴道缓释片联合甲硝唑阴道泡腾片治疗复发性细菌性阴道病的疗效观察  

Efficacy Observation of Vitamine C Vaginal Sustained-release Tablets Combined with Metronidazole Vaginal Effervescent Tablets for Recurrent Bacterial Vaginosis

作　　者：平成斌[1] 程小林[2] 郭佶伟[2] 

机构地区：[1]武汉市普爱医院药学部,武汉430033 [2]武汉市普爱医院妇产科,武汉430033

出　　处：《中国药房》2013年第28期2624-2626,共3页China Pharmacy

基　　金：武汉市卫生局临床重点学科研究项目

摘　　要：目的:观察维生素C阴道缓释片联合甲硝唑阴道泡腾片对复发性细菌性阴道病的疗效。方法:将150例复发性细菌性阴道病患者随机均分为3组,A组患者于月经前予甲硝唑阴道泡腾片每晚1片,治疗7 d;B组患者于月经前予维生素C阴道缓释片每晚1片,治疗7 d;C组患者予甲硝唑阴道泡腾片治疗7 d后,在随后的月经干净后给予维生素C阴道缓释片治疗7 d。3组患者均于停药7、30、60、90、120 d后对其疗效进行评价,并观察其不良反应。结果:停药7、30 d后,3组患者的有效率相当,组间比较差异无统计学意义(P>0.05)。停药60、90、120 d后,C组患者的复发率显著低于A、B组,组间比较差异有统计学意义(P<0.05)。3组患者均未见明显不良反应发生。结论:维生素C阴道缓释片联合甲硝唑阴道泡腾片治疗复发性细菌性阴道病疗效较好,复发率较低,用药安全。OBJECTIVE： To observe the therapeutic efficacy of Vitamin C vaginal tablets combined with Metronidazole vaginal effervescent tablets in the treatment of recurrent bacterial vaginosis（BV）. METHODS： 150 patients with recurrent BV were ran- domly divided into 3 groups. Group A was given Metronidazole vaginal effervescent tablets before menstruation once a day for 7 days; group B was given Vitamin C vaginal tablets before menstruation once a day for 7 days; group C was given Metronidazole vaginal effervescent tablets once a day for 7 days and then treated with Vitamin C vaginal sustained-release tablets for 7 days after menstruation. Therapeutic efficacy and ADR of 3 groups were evaluated 7, 30, 60, 90 and 120 days after drug withdrawal. RE- SULTS： Total effective rates of 3 groups 7, 30 days after drug withdrawal; there was no statistical significance among 3 groups （P〉 0.05）. The recurrent rates of group C was lower than group A, B 60, 90, 120 days after withdrawal; there was statistical significance among 3 groups（P〈0.05）. No significant ADR was observed in 3 groups. CONCLUSIONS： Vitamin C vaginal tablets combined with Metronidazole vaginal effervescent tablets is effective and safe for recurrent BV with low relapse rate.

关 键 词：细菌性阴道病 维生素C阴道缓释片 甲硝唑阴道泡腾片 

分 类 号：R711.3[医药卫生—妇产科学]