微波辐射下N-芳基哌嗪盐酸盐的合成  

Synthesis of N-Aryl Piperazinium Chlorides Under Microwave Irradiation

作　　者：富利祥[1] 徐崇福[1] 陆海玲 郑黄利[1] 赵萌萌[1] 宋蕴丽[1] 杨扬[1] 

机构地区：[1]常州大学石油化工学院江苏省精细石油化工重点实验室,江苏常州213164 [2]富德(常州)能源化工发展有限公司,江苏常州213100

出　　处：《精细化工》2013年第7期816-820,834,共6页Fine Chemicals

基　　金：国家自然科学基金(21076027)~~

摘　　要：取代苯胺与N,N'-双(2-氯乙基)胺盐酸盐在二乙二醇单甲醚溶剂中,微波辐射下一步合成了10种N-芳基取代哌嗪盐酸盐,反应在3～4 min内完成,产率36.9%～75.4%。结果表明,苯胺芳环上的取代基对N-芳基哌嗪化反应有着可合理预测的电子效应及位阻效应。与常规加热法相比,微波辐射法具有反应时间短、产率高、操作简便和环境友好等特点。所有产物的分子结构用IR、1HNMR和MS进行了表征。An efficient one-pot method is used to prepare a series of N-aryl substituted piperazine hydrochloride from substituted aniline and N,N′-bis（2-chloroethyl）amine hydrochloride in 2-（2-methyloxyethoxy）ethanol under microwave irradiation.The reactions were completed in 3-4 min with 36.9%-75.4% yields.It is confirmed by the experimental results that substituents on the benzene rings of the substituted aniline exerted the same consistent influences in the ongoing N-aryl piperazination as those of plausible prediction.Compared with conventional heating method,the method of microwave irradiation possesses such advantages as less reaction time,high yield,easy operation and environmental benignity.Their molecular structures were characterized by means of IR,1HNMR and MS spectroscopy.

关 键 词：微波辐射 取代苯胺 N-芳基哌嗪盐酸盐 重结晶 精细化工中间体 

分 类 号：TQ316.313[化学工程—高聚物工业] O625[理学—有机化学]