美斯地浓缓释片的制备及其体外释放行为  

Preparation and in vitro release of mestinon sustained-release tablets

作　　者：何丹[1] 谭群友[2] 熊华蓉[1] 王睿[1] 张景勍[1] 

机构地区：[1]重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室,重庆400016 [2]第三军医大学大坪医院野战外科研究所胸外科,重庆400042

出　　处：《中国新药杂志》2013年第14期1713-1716,共4页Chinese Journal of New Drugs

基　　金：教育部博士点基金(20095503120008);重庆市教育委员会首批高等学校优秀人才资助项目(KJ090308)

摘　　要：目的:制备美斯地浓缓释片,并考察其体外释放行为。方法:以羟丙甲基纤维素(HPMC),微晶纤维素、乳糖等为材料制备美斯地浓缓释片,考察释放度测定装置、转速、释放介质对体外累积释放度的影响。结果:测定装置,转速,释放介质的pH值影响因素的f2均大于50,对美斯地浓缓释片的释放均无明显影响。结论:美斯地浓缓释片的体外释放行为符合Higuchi方程,且工艺重现性和稳定性较好。Objective： To prepare mestinon sustained-release tablets and to assess their in vitro release behaviors.Methods： The mestinon sustained-release tablets were prepared by using hydroxypropylmethyl cellulose（HPMC）,microcrystalline cellulose and lactose.The effects of measuring equipment,rotate speed and the pH values of the dissolution media on in vitro drug release rates were studied.Results： The values of between the measuring equipment,rotate speed and the pH values of media were greater than 50.These influencing factors had no obvious effects on its in vitro release.Conclusion： The drug in vitro release behavior from sustained-release tablets fits the Higuchi equation.The reproduction quality and stability are satisfactory.

关 键 词：美斯地浓 缓释片 体外释放 

分 类 号：R943.41[医药卫生—药剂学]