黄芪葛根汤对2型糖尿病大鼠心肌病变的影响  

Huangqi Gegen Decoction on myocardial lesions in type 2 diabetic rats

作　　者：陈艳芬[1] 李卫民[2] 高英[2] 吴清和[2] 唐春萍[1] 杨超燕[1] 陶曙红[1] 

机构地区：[1]广东药学院中药学院,广州510006 [2]广州中医药大学中药学院,广州510006

出　　处：《中国中医基础医学杂志》2013年第7期773-776,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目(81274156);广东省中医药管理局资助项目(2010412);广东省科技计划社会发展类项目(2010B030700058)

摘　　要：目的:观察实验性2型糖尿病大鼠的心肌病理改变,探讨黄芪葛根汤对糖尿病心肌病变的干预作用。方法:采用高脂饲料喂养和链脲佐菌素(STZ)腹腔注射(30mg/kg)的方法诱导2型糖尿病大鼠,黄芪葛根汤连续给药8周后(阳性对照组罗格列酮),分别采用HE染色、Masson染色、透射电镜以及TUNEL实验观察模型大鼠的心肌改变及药物干预作用。结果:黄芪葛根汤可干预糖尿病大鼠心肌组织形态学和超微结构病变,明显减少心肌胶原纤维增生,显著抑制心肌细胞凋亡,且有一定的剂量依赖效应。结论:黄芪葛根汤对2型糖尿病心肌病变具有明显的保护作用。Objective： To observe myocardial pathological changes of diabetic rats, and study the intervention effect of HGD on myocardial pathological changes. Methods： Applying the methods which combined high fat diet with STZ （ip, 30mg/kg） to establish type 2 diabetes rat model, after eight weeks of continuous administration with HGD（ Positive control group, rosiglitazone）, HE staining, Masson staining and transmission electron microscopy and TUNEL assay were respectively used to observe myocardial changes and drug intervention. Results： HGD intervened myocardial changes of diabetic rats in tissue morphology and uhrastructura, significantly reduced myocardial collagen fibers and cardiomyocyte apoptosis in a dose-dependent manner. Conclusion： HGD has a significant protective effect on myocardial pathological changes of type 2 diabetes.

关 键 词：黄芪葛根汤 2型糖尿病 心肌病变 大鼠 

分 类 号：R965[医药卫生—药理学]