脾气虚型HIV/AIDS患者淋巴细胞线粒体功能状态在常温和热应激条件下的改变情况  

Changes of lymphocytes mitochondrial function in room temperature and heat stress conditions in patients with HIV/AIDS of spleen deficiency type

作　　者：孙萌[1] 刘颖[2] 王克林[1] 徐淑玲[1] 孙刚[1] 王笑红[1] 翟志光[1] 杨凤珍[2] 王健[2] 

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700 [2]中国中医科学院艾滋病防治研究中心,北京100700

出　　处：《中国中医基础医学杂志》2013年第7期777-778,784,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金青年基金项目(81102724)-脾气虚HIV/AIDS患者与淋巴细胞受体多样性以及免疫激活的相关研究

摘　　要：研究比较脾气虚证人类获得性免疫缺陷病毒患者(HIV/AIDS患者)与健康人群淋巴细胞在37℃和40℃条件(模拟热应激)下,淋巴细胞线粒体膜电位差异,结果显示脾气虚证HIV/AIDS患者淋巴细胞线粒体膜电位明显下降,特别是在热应激条件下(40℃孵育1h),反映了其机体在发热情况下能量代谢功能的下降,另一方面揭示了HIV/AIDS患者脾气虚病机的部分细胞免疫学基础,为中医药防治HIV/AIDS提供理论支持和依据。The research compare the mitochondrial membrane potential （Aψ） of lymphocytes in healthy people with in HIV/AIDS infector of spleen qi deficiency. The results indicated that the mitochondrial membrane potential （Aψ） of lymphocytes in HIV/AIDS infection was obviously lower than in healthy people, especially in the condition of heat stress （ 1 hour incubation on 40℃ ）, to reflect the function of energy metabolism in the HIV/AIDS infector of spleen qi deficiency descent under the condition of fever, and on the other hand to reveal their pathogenesis of cellular immunology. Through the exploration,the theoretical evidence was provided for HIV/AIDS prevention and cure by Traditional Chinese Medicine.

关 键 词：人类获得性免疫缺陷病毒患者 脾气虚 淋巴细胞 线粒体膜电位 

分 类 号：R512.91[医药卫生—内科学]