抗华支睾吸虫药物研究进展  

Advances on the drugs development against Clonorchis sinensis

作　　者：徐莉莉[1] 姜斌[1] 周晓农[1] 

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾、血吸虫病和丝虫病合作中心,上海200025

出　　处：《国际医学寄生虫病杂志》2013年第4期212-215,共4页International JOurnal of Medical Parasitic Diseases

摘　　要：华支睾吸虫寄生于终宿主的肝胆管内，可引起以肝胆病变为主的华支睾吸虫病。目前用于治疗该病的药物仅有吡喹酮与阿苯达唑。动物实验结果表明，甲苯达唑、蒿甲醚、青蒿琥酯和三苯双脒对感染华支睾吸虫的大鼠均有良好的疗效。小规模临床试验显示，三苯双脒抗虫作用好、不良反应少，有望成为新的抗华支睾吸虫药物。该文就抗华支睾吸虫药物的研究进展进行综述。Clonorchis sinensis parasites in the bile duct of human or animal host, resulting in hepatobiliary pathological changes and causing the clonorchiasis. Drugs currently used to treat the disease are only praziquantel and albendazole. Animal trials indicated that mebendazole, artemether, artesunate and tribendimi- dine had good efficacy in treatment of rats infected with C. sinensis. Tribendimidine will be one of promising new drug to treat C. sinensis infection due to its high efficacy and low toxicity demonstrated in the small scale clinical trials. In this paper, the research progress on the drugs against Clonorchis sinensis was introduced.

关 键 词：华支睾吸虫 吡喹酮 阿苯达唑 甲苯达唑 青蒿素类 三苯双脒 

分 类 号：R383.2[医药卫生—医学寄生虫学]