宿主肝细胞来源分子对红外期疟原虫感染和发育影响的研究进展  

Advances on the effect of host hepatocyte-derived molecules in the development and proliferation of fiver-stage Plasmodium

作　　者：李明星[1] 曹毅[1] 潘卫庆[1] 

机构地区：[1]第二军医大学热带传染病学教研室,上海200433

出　　处：《国际医学寄生虫病杂志》2013年第4期221-224,共4页International JOurnal of Medical Parasitic Diseases

基　　金：国家自然科学基金（81220108019）

摘　　要：疟原虫入侵宿主肝细胞并在其中发育增殖是建立疟疾感染的关键环节，因此该阶段也成为抗疟药物和疫苗研发针对的重要靶标。肝期原虫的入侵和发育涉及多种宿主肝细胞来源分子与疟原虫来源分子的相互作用。近年来的研究陆续发现了一些疟原虫与宿主相互作用中发挥重要功能的宿主肝细胞来源分子。该文就影响子孢子入侵、疟原虫肝细胞内生长发育和营养代谢、宿主对疟原虫免疫反应的肝细胞来源分子研究进展进行综述。The development and proliferation of liver-stage Plasmodium are the key steps of Plasmodium infection, and represent an attractive target for anti-malarial drug and vaccine development. The development of liver-stage Plasmodium involves the molecular mechanism of interaction between parasites and host liver cells. In recent years, researches have identified some important molecules derived from host liver cell involved in host-parasite interaction. This article reviews the research progress on host hepatocyte molecules involved in sporozoite invasion, growth, metabolism and host immunoreaction.

关 键 词：疟原虫 肝期 宿主来源分子 

分 类 号：R531.3[医药卫生—内科学]