肿瘤多药耐药的发生机制及逆转策略  

Progress in Study on Mechanism of Multidrug Resistance in Tumor and Reversal Strategy

作　　者：揭惠[1] 酉明巧[1] 刘辉[1] 张虎[1] 吴敏[1] 

机构地区：[1]成都医学院药学院,四川成都610083

出　　处：《中华中医药学刊》2013年第7期1686-1690,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：成都医学院创新性实验资助项目(CX2010032)

摘　　要：肿瘤多药耐药(multidrug resistance,MDR)的产生是一个多机制联合作用的结果,包括ABC转运子超家族成员的异常增多,耐药基因的异常表达,细胞因子的辅助调节,药物作用靶点下调等。MDR是肿瘤化疗失败的主要原因之一,以致MDR逆转剂的研究已成为国内外研究热点。目前MDR逆转剂的研究主要集中在蛋白质、基因、细胞因子等水平。对肿瘤多药耐药的发生机制及其逆转措施的最新进展作一全面深入的综述。Tumor multidrug resistance（MDR）is a result of complex mechanism with union actions of many factors which include abnormal increase of ATP-binding cassette transporter,abnormal expression of drug-resistant genes,the auxiliary regulator of cytokines and decrease of drug targets,etc.MDR is one of the main reasons to the failure of tumor chemotherapy,so study on MDR reversal agents becomes the focus in the world.At present,researches of MDR reversal agents chiefly focus on protein,cytokines and related genes levels,etc.This article will make a summary on the pathogenesis of multidrug resistance in tumor and the main reversal measures.

关 键 词：抗药性 肿瘤 机制 逆转 中药 

分 类 号：R285.5[医药卫生—中药学]