卡泊芬净对成年人白血病真菌感染的疗效分析  

Efficacy of caspofungin in treatment of fungal infections in adults with leukemia

作　　者：陈荣华[1] 郭树霞[1] 张晓娟[1] 

机构地区：[1]郑州人民医院血液科,河南郑州450000

出　　处：《中华医院感染学杂志》2013年第14期3504-3505,3508,共3页Chinese Journal of Nosocomiology

基　　金：河南省自然科学基金资助项目(0511043700)

摘　　要：目的探讨卡泊芬净对成年人白血病并发真菌感染的疗效及安全性,探究卡泊芬净对白血病真菌感染患者的治疗效果。方法将医院收治经氟康唑治疗无效的24例白血病合并真菌感染的患者作为研究对象,年龄23～64岁,所有患者均采用卡泊芬净治疗,对患者接受治疗后7d及14d的疗效及真菌清除率进行调查分析,同时对治疗安全性进行分析。结果患者在接受治疗7d时,痊愈2例、好转15例;进步2例及无效5例,治疗有效率为70.83%,接受治疗14d时治愈4例、好转17例,进步2例及无效1例,治疗有效率为87.50%,两个时间治疗有效率差异有统计学意义(P<0.05);患者在接受治疗7d时真菌清除5株,清除率20.83%,未清除12株,未清除率50.00%,治疗14d后的真菌清除株数18株,清除率75.00%,未清除2株,未清除率8.33%。结论卡泊芬净对成年人白血病并发真菌感染的治疗具有良好的临床疗效及真菌清除效果,同时具有良好的安全性,值得在临床中推广。OBJECTIVE To investigate the efficacy and safety of caspofungin in treatment of fungal infections in the adults with leukemia and explore the therapeutic effect of caspofungin on the treatment of leukemia complicated with fungal infections.METHODS Totally 24 cases of leukemia patients complicated with fungal infections who were invalid for the treatment with fluconazole were enrolled in the study,all the patients aged setween 23 and 64 years old,were treated with caspofungin,then the efficacy and the bacterial clearance rate were compared between 7days and 14 days after the treatment,and the clinical safety of the treatment was evaluated.RESULTS Seven days after the treatment,2 cases were cured,15 cases improved,progress in 2 cases,and 5 cases ineffective,with the effective rate of 70.83%;14 days after the treatment,4 cases were cured,17 cases improved,2 cases in progression,and 1case ineffectively,with the effective rate of 87.5%the difference in the effective rate of treatment was significant（P0.05）.On the seventh day after the treatment,there were 5strains of fungi cleared with the clearance rate of 20.83% and 12（50.00%）strains without being cleared,with 7（29.17%）strains unknown;on the 14th day after the treatment,there were 18（75.00%）strains of fungi cleared and 2（8.33%）strains without being cleared.CONCLUSIONCaspofungin can achieve good clinical efficacy as well as the fungal clearance effect on the treatment of the leukemia adults complicated with fungal infections,with safety high,thus it is worthy to be promoted in the hospital.

关 键 词：卡泊芬净 白血病 真菌感染 

分 类 号：R978.1[医药卫生—药品]