不同基质及促渗剂对姜黄素脂质体凝胶经皮渗透的影响  

Effects of Gel Matrixes and Penetration Enhancers on Skin Permeability of Curcumin Liposomal Gel

作　　者：吴青青[1,2] 袁菱[1,2] 陈彦[1] 张振海[1] 周蕾[1,2] 

机构地区：[1]江苏省中医药研究院,国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]江苏大学药学院,江苏镇江212013

出　　处：《中国医药工业杂志》2013年第7期686-690,共5页Chinese Journal of Pharmaceuticals

基　　金：江苏省自然科学基金项目(BK2010593);江苏省中医药领军人才项目(LJ200913)

摘　　要：考察了凝胶基质种类及浓度和促渗剂对姜黄素脂质体凝胶经小鼠离体皮肤的累积渗透量及皮肤滞留量的影响。所得优化处方为:以1%卡波姆为凝胶基质,加入2%月桂氮酮和2%薄荷醇为复合促渗剂。所得制品的24 h累积渗透量、稳态渗透速率及皮肤滞留量均显著高于姜黄素脂质体。The effects of types and concentrations of gel matrix and the penetration enhancers on the cumulative penetration and retention amount of curcumin liposomal gel were investigated. The optimal matrix of liposomal gel was Carbomer with the concentration of 1%, and combined enhancers of 2% Azone and 2% menthol had the best enhancing effect. Compared with the curcumin liposomes, the liposomal gel had higher cumulative penetration amount, steady state permeation rate and skin retention, after 24 h.

关 键 词：姜黄素 脂质体凝胶 凝胶基质 促渗剂 经皮渗透 

分 类 号：R944.9[医药卫生—药剂学]