呼出气一氧化氮与儿童哮喘控制测试和支气管激发试验指标相关性研究  

Relationship of fractional exhaled nitric oxide with childhood asthma control test and bronchial provocation test

作　　者：骆学勤[1,2,3,4] 刘恩梅[1,2,3,4] 符州 龚财惠[1,2,3,4] 罗健 

机构地区：[1]重庆医科大学附属儿童医院 [2]儿童发育疾病研究教育部重点实验室 [3]儿科学重庆市重点实验室 [4]重庆市儿童发育重大疾病诊治与预防国际科技合作基地,重庆400014

出　　处：《中国实用儿科杂志》2013年第7期533-536,共4页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨呼出气一氧化氮(FENO)与儿童哮喘控制测试(C-ACT)、支气管激发试验(BPT)指标的相关性。方法选取2011年3月至2011年9月于重庆医科大学附属儿童医院哮喘门诊就诊的哮喘患儿48例,年龄5～12岁,根据2009年全球哮喘防治创议(GINA)标准分为控制组17例、部分控制组14例和未控制组17例,分别完成FENO测定、肺功能检查及C-ACT问卷,第1秒用力呼气容积占预计值的百分比(FEV1%)合格的患儿完成支气管激发试验,记录出现FEV1下降超过20%的乙酰甲胆碱浓度(PC20),分析三组间的FENO、C-ACT、FEV1%、BPT结果及其相关性。结果哮喘儿童FENO几何均数(22.5±2.0)×10-9mol/L,未控制组FENO明显高于控制组和部分控制组。三组间的C-ACT、FEV1%、BPT结果差异均有统计学意义。FENO与FEV1%呈弱的负相关,PC20与FEV1%有弱相关,而FENO、C-ACT、PC20三者间均无明显相关性。结论在哮喘的管理和评估中,FENO需与肺功能、BPT、C-ACT等其他指标联合应用。Objective To find out the fractional exhaled nitric oxide（FENO） in different control level and the relation- ship of FENO with childhood asthma control test （C-ACT） and bronchial provocation test（BPT）. Methods Totally 48 asthmatic children who underwent routine checkups since March 2011 through September 2011 were enrolled in the study. The patients completed the detection of FENO, they also underwent pulmonary function test （PFT）, bronchial provocation test （BPT）and C-ACT. Those indexes and relationships were analyzed in different control groups. Results The geometrical mean FENO of asthmatic children was （22.5 ±2.0）× 10^-9 mol/L. Uncontrolled group had higher FE- NO than controlled group and partly controlled group, and FENO was slightly related to FEVI% Pred, so did PC20, but no relevance had been found between FENO, C-ACT or PC20. Conclusion FENO can be an useful tool in managing asthma when used together with C-ACT, PFT and BPT.

关 键 词：儿童哮喘 呼出气一氧化氮 儿童哮喘控制测试 支气管激发试验 

分 类 号：R72[医药卫生—儿科]