中国人群使用心律平与胺碘酮治疗阵发性室上性心动过速的Meta分析  

A Meta-Analysis of Propafenone Versus Amiodarone in Treating Paroxysmal Supraventricular Tachycardia

作　　者：尹延伟[1] 许瑞佳[1] 胡爱民[1] 孙倩倩 刘宏利[1] 王琦[1] 侯志贞[1] 

机构地区：[1]空军总医院急诊部,北京100142 [2]空军北京劲松干休所,北京100021

出　　处：《循证医学》2013年第3期152-156,共5页The Journal of Evidence-Based Medicine

摘　　要：目的探讨中国人群使用心律平与胺碘酮治疗阵发性室上性心动过速的疗效及安全性。方法采用RevMan5.1.4版本软件中的Meta分析,对2011年8月以前有关中国人群使用心律平与胺碘酮治疗阵发性室上性心动过速的疗效及安全性的文献进行综合分析。结果检索并纳入文献8篇,患者561例。心律平与胺碘酮治疗阵发性室上性心动过速的有效率及不良反应发生率的合并优势比(95%可信区间)分别为0.84(0.40～1.78,P=0.65)与1.17(0.76～1.79,P=0.48)。结论基于目前的研究发现,中国人群使用心律平与胺碘酮治疗阵发性室上性心动过速的有效率及不良反应发生率差异均无统计学意义,临床上可根据患者病情酌情使用。Objective To evaluate the efficacy and safety of Propafenone and Amiodarone in treating Chinese paroxysmal supraventricular tachyeardia （PSVT） cases. Methods We performed the meta-analysis synthesizing the data from previous published studies （up to August 2011 ） to evaluate the efficacy and safety of Propafenone and Amiodarone in Chinese PSVT cases. Meta-analysis was done using software Review Manager（Version 5.1.4）. Results A total of 8 studies including 561 Chinese cases were identified. The combined ORs（95%CI） of clinical efficiency and incidence of adverse reactions were 0.84 （0.40-1.78, P=0.65） and 1.17 （0.76-1.79,P=0.48）. Conclusions For Chinese population, the chnical efficiency and incidence of adverse reactions of Propafenone and Amiodarone in treating PSVT were similar. The selection of these two drugs should be based on the patient＇s condition.

关 键 词：阵发性室上性心动过速 心律平 胺碘酮 META分析 

分 类 号：R541.71[医药卫生—心血管疾病]