山芝麻对大鼠溃疡性结肠炎的影响  

Effect of Helicteres angustifolia on Rats with Ulcerative Colitis

作　　者：高玉桥[1] 苏丹[2] 胡莹[1] 林慧[1] 张文霞[1] 戴卫波[1] 

机构地区：[1]广州中医药大学附属中山医院,广东中山528400 [2]电子科技大学中山学院,广东中山528400

出　　处：《中药材》2013年第4期597-600,共4页Journal of Chinese Medicinal Materials

基　　金：中山市科技计划(医疗卫生)立项资助项目(20102A108)

摘　　要：目的:探讨山芝麻水提物对大鼠溃疡性结肠炎(UC)的药效作用及其机制。方法:将SD大鼠随机分成6组(正常对照组、模型组、柳氮磺胺吡啶组及山芝麻高、中、低剂量组),采用三硝基苯磺酸(TNBS)灌肠法,制备溃疡性结肠炎大鼠模型。第2天开始灌胃给药,在第3周处死动物后,观察药物对大鼠血清中白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、肿瘤因子-α(TNF-α)表达水平以及结肠组织病理改变的影响。结果:山芝麻水提物能显著升高溃疡性结肠炎大鼠血清中抑炎因子IL-10水平,降低其促炎因子IL-6、TNF-α水平,并改善大鼠的组织学损伤和症状。结论:山芝麻水提物能平衡溃疡性结肠炎大鼠血清中炎症因子水平,并改善其病理组织损伤和症状。Objective ： To investigate the effect of aqueous extract of Helicteres angustifolia （ AEHA ） on rats with ulcerative colitis （UC） and its mechanism. Methods ： SD rats were randomly divided into 6 groups ： normal control group, the model group, SASP group and 21.6,10. 8,5. 4 g/kg AEHA group with 10 rats in each group. UC was induced by clyster with 2,4,6-trinitrobenzesulphonic acid（TNBS）in rats. Rats were given AEHA by gavage for 3 weeks,and sacrificed at day 22nd to determine the expressions of IL-10,IL-6 and TNF-a in blood. Colon tissue pathological changes were investigated. Results：Compared with the control group, the expression of IL-10 was increased, the expressions of IL-6 and TNF-a were decreased in AEHA treatment groups. The colon tissue damages and the symptoms of UC rats were improved. Conclusion：AEHA can keep balance of inflammatory factors in blood of UC rats, and improve it＇s colon tissue damages and symptoms.

关 键 词：山芝麻 溃疡性结肠炎 肿瘤坏死因子-Α 白细胞介素-6 白细胞介素-10 

分 类 号：R285.5[医药卫生—中药学]