噻环乙胺对大鼠不同脑区内源性硫化氢浓度的影响  

Effect of Tiletamine on the Endogenous Hydrogen Sulfide Content in Different Brain Regions of Rats

作　　者：唐雨顺[1] 李林[2] 邹晶[3] 李大鹏[3] 蔺东启[3] 姜胜[3] 范宏刚[3] 

机构地区：[1]锦州医学院畜牧兽医学院,辽宁锦州121001 [2]沈阳农业大学畜牧兽医学院,辽宁沈阳110866 [3]东北农业大学动物医学学院,黑龙江哈尔滨150030

出　　处：《中国兽医杂志》2013年第6期17-19,共3页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金(31001092);高等学校博士学科点专项科研基金(新教师)(20102325120016);中国博士后科学基金(2011M501057)

摘　　要：动态观察噻环乙胺对大鼠不同脑区内源性H2S浓度的影响,以探讨其是否参与噻环乙胺全麻过程。选取SD大鼠84只,随机分为对照组和高、低剂量组(腹腔注射噻环乙胺60mg/kg体重、30mg/kg体重),每个剂量组又分为麻醉组、恢复Ⅰ组和恢复Ⅱ组等3个亚组。在相应的时期断头取脑,分离各部分脑区,测定脑内H2S浓度。结果表明,内源性H2S可能参与了噻环乙胺麻醉过程,在大脑皮层、中脑、海马表现出剂量依赖性,且与大鼠行为学变化具有一定的相关性。To explain whether endogenous dynamic effects of tiletamine on Hz S content in HzS is involved in tiletamine anesthesia by observing the different brain regions of rats, 84 SD rats were randomly divided into control group, high dose group （ip tilelamine 60 mg/kg） and low dose group （ip tilelamine.30 mg/kg）. Each group was divided into three subgroups of maintenance of anesthesia, recovery from anesthesia Ⅰ and recovery from anesthesia Ⅱ , according to their anesthesia state. The brains were removed and various parts of brain regions were separated in the corresponding period, the contents of H2S in different brain regions of rats were measured by spectrophotometry. The results suggest that endogenous Hz S may be involved in tiletamine anesthesia process and show dose-dependeney in the regions of the eere- bral cortex, midbrain, hippocampus, it has some correlation with the behavioral changes of rats.

关 键 词：噻环乙胺 麻醉 内源性硫化氢 

分 类 号：S859.791[农业科学—临床兽医学]