血清S100β、MBP含量变化与糖尿病周围神经病变的相关性研究  

The correlation of serum S100β and myelin basic protein level with diabetic peripheral neuropathy

作　　者：丛艳[1] 李金萱[1] 秦晓凤[1] 胡刚[1] 武传昇[1] 王敏[1] 

机构地区：[1]连云港市东方医院中西医结合科,连云港222042

出　　处：《世界临床药物》2013年第7期409-411,共3页World Clinical Drug

基　　金：江苏省连云港市卫生局科研基金资助项目(项目编号:1127)

摘　　要：目的研究S100β、髓鞘碱性蛋白(MBP)含量的变化与糖尿病患者周围神经病变的关系及其意义。方法 60例糖尿病患者分为糖尿病无神经病变组(n=30)和糖尿病并发神经病变组(n=30),并纳入30例健康者作为健康对照组。上述研究对象血清中S100β、MBP含量以酶联免疫吸附法检测。结果糖尿病并发周围神经病变组血清S100β、MBP阳性率较健康对照组和无神经病变组均升高,差异有统计学意义(P<0.05)。结论血清MBP及S100β蛋白测定可能成为糖尿病周围神经病变的早期诊断和随访指标之一。Objective To investigate the correlation of serum myelin basic protein （MBP） and S100β level with diabetic peripheral neuropathy. Methods Sixty diabetic patients were divided into group of diabetic patients without neuropathy （n=30） and group of diabetic peripheral neuropathy （DPN） （n=30）, and 30 healthy people were included as healthy controls. The enzyme linked immunosorbent assay was used to detect the protein expression level of MBP and S100β, Results Compared with the healthy control group and the group of diabetic patients without neuropathy, the serum MBP and S100β positive rate in DPN group were increased significantly （P〈0.05）. Conclusion The determination of serum MBP and S100β may be used as a prophase DPN diagnostic target and its follow-up index.

关 键 词：糖尿病周围神经病变 髓鞘碱性蛋白 S100Β蛋白 

分 类 号：R587.2[医药卫生—内分泌]