Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome  

作　　者：Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng 

机构地区：[1]Key Laboratory of Molecular Virology and Immunology, Institut Pas- teur of Shanghai, Shanghai Institutes for Biological Sciences, Graduate University of Chinese Academy of Sciences, Shanghai 200025, China [2]College of Life Science, Shandong Normal University, Jinan, Shandong 250014, China [3]College of Life Science, Henan Normal University, Xinx- iang, Henan 453007, China [4]Department of lnfectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China

出　　处：《Cell Research》2013年第7期965-968,共4页细胞研究（英文版）

基　　金：We thank Dr Warren Strober （National Institutes of Health, USA） for providing the Nlrp3-deficient mice, Dr Vishva Dixit （Genentech, Inc., USA） for providing Asc-deficient mice, Dr Jfirg Tschopp （University of Lausanne, Switzerland） for provid- ing shRNA constructs. We also thank Dr Xudong Zhu （Nankai University, China） for helpful discussion and our colleague Ms Cuili Dong for excellent technical assistance. This work was sup- ported by grants from 100 Talent Program of the Chinese Acad-emy of Sciences, the National Natural Science Foundation of China （91029707, 31170868, 812111134, 31100622）, Shanghai Natural Science Foundation （11ZR1442600）, Novo Nordisk-CAS Research Foundation, SA-SIBS Scholarship Program, Chinese Postdoctoral Science Foundation （20110490752） and Postdoctoral Research Foundation of Shanghai Institutes for Biological Sci- ences （2011 KIP513）, as well as grants from the National Key Ba- sic Research Program （2013CB531600） and National Science and Technology Major Project （2012ZX 10002007-003） of China.

摘　　要：Dear Editor, Many opportunistic fungi are devastating pathogens that cause lethal infection. Cryptococcus neoformans （C. neoformans） is such a fungus that mainly infects im- munocompromised hosts such as AIDS patients as well as organ transplant recipients, and causes cryptococco- sis including life-threatening meningoencephalitis [1]. Cryptococcal meningitis affects about a million AIDS patients and causes 625 000 deaths in the world yearly [2]. The disease also occurs in apparently immunocompetent individuals [3]. However, host immune responses to C. neoformans are not well studied.

关 键 词：隐球菌 生物膜 真菌病原体 激活 菌株 临床 器官移植 脑膜脑炎 

分 类 号：S763[农业科学—森林保护学] TQ460.38[农业科学—林学]