肠球菌fsr群体感应系统的研究进展  

The fsr quorum sensing system in Enterococci-A review

作　　者：刘凌[1] 董卫超[1] 杜向党[1] 

机构地区：[1]河南农业大学牧医工程学院,郑州450002

出　　处：《中国人兽共患病学报》2013年第7期719-723,共5页Chinese Journal of Zoonoses

基　　金：国家自然基金(No.31001086);中国博士后基金(No.20100480851)资助~~

摘　　要：肠球菌现已成为人和动物感染的重要机会病原菌。肠球菌fsr群体感应系统在明胶酶和丝氨酸蛋白酶的产生,生物膜的形成以及在宿主感染部位的扩散等方面发挥重要的调控作用。深入认识肠球菌fsr群体感应系统具有重要意义,以fsr群体感应系统为靶点,可设计和发展新型"抗毒力"抗生素,为治疗肠球菌感染提供新的策略和手段。Enterococci have emerged as important opportunistic pathogens that cause animal and human infection. The fsr quorum sensing system in Enterococci has played a vital regulatory role in the production of gelatinase and serine protease, biofilm development and its dissemination in primary infection site. Further elucidation of the fsr quorum sensing system can give aid to the rational design and development of the novel “anti-virulence” antibiotic and use it as the antimicrobial target, which can provide the new strategies and methods in the treatment of enterococcal infections.

关 键 词：肠球菌 群体感应 致病性 抗菌靶点 

分 类 号：R378.1[医药卫生—病原生物学]