外周动脉僵硬度与左心室舒张功能的相关性研究  

The Relationship between Artery Stiffness and Left Ventricular Diastolic Function in Patients with Multiple Cardiovascular Risks

作　　者：李蕾[1] 葛辉玉[2] 左佳薇[3] 于海奕[1] 冯新恒[1] 李昭屏[1] 高炜[1] 

机构地区：[1]北京大学第三医院心内科、卫生部心血管分子生物学与调节肽重点实验室及分子心血管学教育部重点实验室,北京市100191 [2]北京大学第三医院超声诊断科,北京市100191 [3]北京市第六医院功能检查科

出　　处：《中国超声医学杂志》2013年第7期601-605,共5页Chinese Journal of Ultrasound in Medicine

摘　　要：目的探讨外周动脉僵硬度与左心室舒张功能的相关性。方法根据二尖瓣舒张早期与二尖瓣环舒张早期峰值速度的比值(E/Em),将79例心血管高危患者分为舒张功能不全组(E/Em≥10,n=25)和对照组(E/Em<10,n=54)。采用ET技术测量颈总动脉弹性参数及硝酸甘油诱导的肱动脉内径变化率,比较两组间的差异,评价外周动脉僵硬度与左心室舒张功能的相关性。结果舒张功能不全组动脉僵硬度明显高于对照组(P>0.05),且与左心室舒张功能的多项指标明显相关(P<0.05)。结论外周动脉僵硬度与左心室舒张功能密切相关,可能是左心室舒张功能不全的重要影响因素,对左心室功能不全具有一定的预测价值。Objective To evaluate the relationship between artery stiffness and left ventricular diastolic func-tion. Methods A total of 79 patients with multiple cardiovascular risks were recruited and divided into two groups according to the value of E/Era： diastolic dysfunctional group （E/Em≥ 10, n = 25） and control group （E/Em〈 10, n=54）. The arterial stiffness parameters of carotid artery and endothelium-independent dilation （EID） of brachial artery were evaluated by ET to evaluate the difference between the two groups and the association between artery stiffness and left ventricular diastolic function. Results The arterial stiffness parameters of carotid artery and EID of brachial artery in diastolic dysfunctional group were higher than that in controls （P〉0.05）, and were associated to diastolic function parameters of left ventricular （P〈0.05）. Conclusions The arterial stiffness is closely related to the diastolic function of left ventricular, and maybe an important factor to impact on it. The increased arterial stiffness is useful in predicting left ventricular diastolic dysfunction in patients with multiple cardiovascular risks.

关 键 词：动脉僵硬度 左心室舒张功能不全 血管回声跟踪技术 

分 类 号：R540.45[医药卫生—心血管疾病]