肌源干细胞在组织工程和再生医学的应用  

Application of muscle-derived stem cells in tissue engineering and regenerative medicine

作　　者：丁维进[1,2,3] 苏志达[2] 江华[1,2] 

机构地区：[1]解放军第264医院美容整形科,山西省太原市030001 [2]解放军第二军医大学长征医院整形外科,上海市200003 [3]解放军第二军医大学长征医院神经科学研究中心,上海市200003

出　　处：《中国组织工程研究》2013年第23期4328-4333,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:肌卫星细胞是肌组织损伤后修复的主要细胞来源,在肌组织再生研究领域受到广泛关注。目的:综述肌源干细胞生物学特点及在组织工程和再生医学领域的应用,探讨肌源干细胞的临床应用价值和前景。方法:应用计算机检索维普数据库和Pubmed数据库中2000年1月至2011年4月关于肌源干细胞研究应用的文章,在标题和摘要中以"肌源干细胞,肌卫星细胞,组织工程,再生医学,成体干细胞"或"MDSCs,MSCs,ASCs,regenerative medicine;tissu eengineering"为检索词进行检索。选择文章内容与肌源干细胞研究应用相关文献,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到189篇文献,根据纳入标准选择25篇文献进行综述分析。结果与结论:已有的动物实验和成功的临床试验表明,结合基因工程技术和组织工程的基本原则,以肌源干细胞为基础的组织工程化组织和细胞学治疗可以通过安全的措施应用于各种骨骼肌疾病、心肌疾病、泌尿系统和神经系统,为临床医生及相关疾病领域患者提供良好治愈前景。但肌源干细胞研究仍面临着许多问题。BACKGROUND： Muscle satellite.cells are a main cell source for the repair of muscle tissue injury, and have been paid extensive attention in the study of muscle tissue regeneration. OBJECTIVE： To summarize the biological properties of muscle-derived stem cells and its application in the field of tissue engineering and regenerative medicine, and to explore the clinical application value and perspective of muscle-derived stem cells. METHODS： We retrieved Vip database and PubMed database for articles concerning the application of muscle-derived stem cells published from January 2000 to April 2011. In titles and abstracts, the key words were ＂muscle-derived stem cells, muscle satellite cells, tissue engineering, regenerative medicine, adult stem cells, MDSCs, MSCs, ASCs＂. Articles addressing the application of muscle-derived stem cells were included, and those in the same field published recently or in authorized journals were included. 189 literatures were primarily collected, and a total of 25 literatures were included according to the inclusiQn criteria. RESULTS AND CONCLUSION： Animal experiments and success clinical experiments suggested that in combination of genetic engineering and tissue engineering, tissue engineered tissues and cytological therapy based on muscle-derived stem cells can be used in various skeletal muscle diseases, myocardial diseases, urinary system and nervous system by safe measures. This provides a good healing perspective for clinical physicians and patients, but the study of muscle-derived stem cells still faced many problems.

关 键 词：干细胞 干细胞学术探讨 肌源干细胞 肌卫星细胞 组织工程 再生医学 成体干细胞 分离培养 骨组织工程 血管再生 

分 类 号：R318[医药卫生—生物医学工程]