输卵管妊娠患者血清VEGF的水平与磁共振成像表现的关系  

Association between serum vascular epithelial growth factor and magnetic resonance imaging features in patients with fallopian pregnancy

作　　者：江魁明[1] 王亚[1] 侍丽[1] 钟喜[1] 董天发[1] 唐文艳[1] 张家云[1] 

机构地区：[1]广州医学院第三附属医院放射科,510150

出　　处：《中华生物医学工程杂志》2013年第2期144-147,共4页Chinese Journal of Biomedical Engineering

基　　金：广州荔湾区科技和信息化局计划项目（20121214025）

摘　　要：目的 对比输卵管妊娠患者与早期宫内妊娠孕妇血清VEGF的浓度,以及输卵管妊娠患者的磁共振成像（MRI）表现与其VEGF水平的关系.方法 随机收集2010年1月至2011年6月在本院妇科门诊和住院诊断并经手术病理证实的输卵管妊娠的患者31例[停经时间（40.5±7.1）d],以及因诊断早孕准备行人工流产术的正常宫内妊娠30例[停经时间（37.9±6.4）d].两组研究对象均于确诊妊娠后第2天空腹取肘静脉血,使用ELISA法检测血清中的VEGF水平.31例输卵管妊娠患者则于术前行盆腔平扫和增强MRI检查,分析患者的MRI表现与其VEGF水平的关系.结果 输卵管妊娠患者血清VEGF浓度明显高于早期宫内妊娠的孕妇[（289.2±45.3） ng/L比（19.1±6.3）ng/L,P＜0.05].输卵管妊娠患者囊胚大小、出血、强化程度和宫腔蜕膜化积液均与血清VEGF浓度有关（均P＜0.05）,而妊娠部位、盆腔积液与血清VEGF浓度无关（均P＞0.05）.结论 输卵管妊娠患者血清VEGF浓度显著高于早期宫内妊娠者,并可能影响囊胚的大小、强化程度、出血和宫腔蜕膜化积液.Objective To compare the level of serum vascular epithelial growth factor （VEGF） in patients with fallopian pregnancy and healthy controls with premature intrauterine pregnancy, and to examine the association between magnetic resonance imaging （MRI） features of fallopian pregnancy and the level of VEGF. Methods Thirty-one patients with pathology-diagnosed fallopian pregnancy [menopausal period： （40.5±7.1） days] and 30 healthy controls with premature intrauterine pregnancy pending to receive artificial abortion [menopausal period： （37.9±6.4） days ] in the out-patient and in-patient departments of The Third Affiliated Hospital, Guangzhou Medical College between January 2010 and June 2011 were randomly recruited. Fasting venous blood was sampled at day 2 following confirmation of the diagnosis of pregnancy, which entailed assessment of VEGF by enzyme-linked immunosorbent assay （ELISA）. The 31 patients with fallopian pregnancy underwent plain and contrast-enhanced pelvic MRI preoperatively for determination of the association between MRI features and VEGF. Results Patients with fallopian pregnancy yielded a significantly higher level of serum VEGF [ （289.2±45.3） ng/L vs （19.1±6.3 ） ng/L, P〈0.05 ] than those with premature intrauterine pregnancy. Serum VEGF concentration was associated with the size of the ectopic gestational sacs, the volume of hemorrhage, the extent of enhancement and presence of uterine decidual hydrops （all P〈0.05）, but not associated with the location of fallopian pregnancy and pelvic hydrops （both P〉0.05）. Conclusion The level of serum VEGF in fallopian pregnancy is significantly higher than that in early intrauterine pregnancy and is associated with the size of ectopic gestational sacs, volume of hemorrhage, enhancement and presence of uterine decidual hydrops.

关 键 词：妊娠 输卵管 血管内皮生长因子类 磁共振成像 

分 类 号：R44[医药卫生—诊断学] R714[医药卫生—临床医学]