急性胰腺炎患者血清细胞因子水平的动态变化及其临床价值  

Dynamic changes of serum cytokines in acute pancreatitis and its clinical value

作　　者：金培声[1] 任宗海[1] 应卫星[1] 叶方鹏[1] 

机构地区：[1]温州医科大学附属第三医院消化内科,浙江温州325200

出　　处：《温州医学院学报》2013年第7期468-470,共3页Journal of Wenzhou Medical College

基　　金：温州市卫生局科研基金资助项目(2012B024)

摘　　要：目的:探讨急性胰腺炎(AP)患者血清细胞因子水平的动态变化及其对诊断和病情评估的意义。方法:选取在我院消化科诊断为AP的患者60例,根据病情分为轻症急性胰腺炎(MAP)组和重症急性胰腺炎(SAP)组,均30例。采集患者发病后第1、第4和第7天血液样本,用酶联免疫吸附试验(ELISA)测定血清中细胞因子水平。结果:MAP组,血清白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)和血小板活化因子(PAF)的浓度第4天较第1天显著升高,IL-1和IL-8的浓度没有明显变化;SAP组,血清IL-1、IL-6、IL-8、TNF-α和PAF的浓度第1天显著高于第4天,IL-10的浓度没有显著变化。结论:MAP和SAP的血清细胞因子水平变化规律不同,对MAP和SAP的鉴别诊断以及病情评估具有重要的临床价值。Objective： To investigate the dynamic changes of serum cytokines on the clinical diagnosis and evaluation of acute pancreatitis. Methods： Sixty acute pancreatitis patients recruited and treated in our hospital were selected. The patient＇s serum cytokines were measured with enzyme-linked immune sorbent assay （ELISA） at the days of 1, 4 and 7 after the onset of acute pancreatitis. Results： In the mild acute pancreatitis group, serum concentrations of IL-6, IL-10, TNF-α, and PAF at the day of 4 were significantly higher than that at the day 1. In the sever acute pancreatitis group, serum concentrations of IL-1, IL-6, IL-8, TNF-α, and PAF at the day 1 are significantly higher than that at the day 4. Conclusion： The dynamic changes of serum cytokines are different in the patients with mild acute pancreatitis and sever acute pancreatitis. It is of great importance with regarding to the final diagnosis and evaluation of acute pancreatitis.

关 键 词：胰腺炎 急性 细胞因子类 动态变化 酶联免疫吸附试验 

分 类 号：R657.5[医药卫生—外科学]