登革病毒受体的研究进展  

Research progress of dengue virus receptor

作　　者：房树玉[1] 吴艳花[1] 安静[1] 

机构地区：[1]首都医科大学微生物学教研室,北京100069

出　　处：《微生物学免疫学进展》2013年第3期62-66,共5页Progress In Microbiology and Immunology

基　　金：国家自然科学基金(30870135);北京教育委员会科技计划项目(SQFM 2012 1002 5005)

摘　　要：登革病毒(Dengue virus,DENV)是登革热(DF)、登革出血热和登革休克综合征(DHF/DSS)的病原体。根据包膜蛋白的抗原性的不同,DENV可分为4个血清型,即DENV1～4。由于血清型比较复杂,目前关于病毒受体仍未得出明确一致的结论。但近几年取得了一些引人注目的进展,比如研究发现甘露糖受体(MR)、CLEC5A等作为DENV的受体,可能在病毒进入宿主细胞过程中发挥重要作用。为此,就近几年关于DENV受体以及病毒进入细胞的机制作一综述。The dengue virus （DENV） is the causative agent for dengue fever （DF）, dengue hemorrhagic fever（ DHF} and dengue shock syndrome （ DSS} and has four distinct serotypes （DENV1-4）. In recent decades, incidence of dengue dis- ease has increased 30-fold, putting a thread to half the world＇ s population at high infection risk living in dengue-endemic areas. However, the pathogenesis of the disease is still poorly understood. The virus binding with its host cell is not only a first and critical step in their replication cycle, but also a key factor for the pathogenicity. Presently there have been signifi- cant advances in understanding interactions in between DENYs and their target cells such as dendritic cells （DC} , macro- phages, endothelial cells and hepatocytes. Although DENV attaches to a variety of receptors on these cells in report, the consensus DENV receptors have not been defined. In this review, we summarize receptors for DENV on different cells iden- tified in recent years.

关 键 词：登革病毒 受体 甘露糖受体(MR) FC受体 C型凝集素结构域家族五成员A(CLEC5A) 

分 类 号：R373.33[医药卫生—病原生物学]