我院1463例药品不良反应报告分析  

Analysis on 1 463 Cases of ADR Reports in Our Hospital

作　　者：高扬[1] 孟莉[1] 姜德春[1] 

机构地区：[1]首都医科大学宣武医院药剂科,北京100053

出　　处：《中国药业》2013年第14期91-92,共2页China Pharmaceuticals

基　　金：北京市卫生系统高层次卫生技术人才培养计划学科骨干项目资助;项目编号:2011-3-096

摘　　要：目的分析医院药品不良反应(ADR)发生情况,为预防和减少ADR提供依据。方法对2009年至2011年收集的1 463例药品不良反应报告作回顾性分析,对ADR程度分级、药物类别、给药途径、涉及的器官、系统分类及临床表现,以及报告人员构成比进行统计分析。结果给药途径以静脉滴注引发ADR最多,共897例(61.31%)。ADR涉及药物以抗感染药最多,共492例(33.63%);其次是脑血管药物和心血管药物,分别是262例(17.91%)和184例(12.58%)。ADR涉及的器官、系统分类及临床表现主要表现为过敏反应,其次为消化系统损害。结论加强对ADR监测工作,有利于促进临床合理用药,保障患者用药安全。Objective To analyze the occurrence situation of adverse drug reactions（ADR） in our hospital to provide the basis for preventing and reducing ADR.Methods The retrospective analysis was conducted on 1 463 cases of ADR report collected in our hospital from 2009 to 2011.The classification of ADR degree,drug category,route of administration,involved organs and systems,clinical manifestations and constituent ratio of the reporters were statistically analyzed.Results The occurrence of ADR caused by intravenous infusion was the highest up to 897 cases（61.31%）.In the ADR-involving drugs,the occurrence of ADR caused by anti-infective drugs was the most up to 492 cases（33.63%）;followed by cerebrovascular and cardiovascular drugs,which were 262 cases（17.91%） and 184 cases（12.58%） respectively.The organs,system classification and clinical manifestations involved in ADR were mainly allergic reactions,followed by damage of the digestive system.Conclusion Enhancing the ADR monitoring work is helpful to promote the clinical rational drug use and protect the patient ＇ s medication safety.

关 键 词：药品不良反应 分析 合理用药 

分 类 号：R969.3[医药卫生—药理学] R954[医药卫生—药学]