多指标正交试验优选苓桂术甘颗粒水提工艺  

Optimization of Water Extraction Process for Preparing Linggui Zhugan Granules by Multi-index Orthogonal Test

作　　者：王权[1] 吴德玲[1] 黄金玲[2] 张伟[1] 刘先华[3] 王桐生[2] 

机构地区：[1]安徽中医药大学药学院,安徽合肥230031 [2]安徽中医药大学中西医结合临床学院,安徽合肥230038 [3]安徽中医药大学科研实验中心,安徽合肥230038

出　　处：《安徽中医学院学报》2013年第4期87-90,共4页Journal of Anhui Traditional Chinese Medical College

基　　金：国家自然科学基金项目(30973707);安徽省科技计划项目(10021303024)

摘　　要：目的优选苓桂术甘颗粒的水提工艺。方法采用正交试验对水提工艺进行优化,以桂皮醛转移率、甘草酸转移率和干膏得率为评价指标,考察加水量、煎煮时间、煎煮次数对提取工艺的影响。结果最佳提取工艺为加8倍量水,提取3次,每次煎煮1h。结论多指标加权考察水提工艺,既符合中药复方的复杂性,又能合理反映水提效果。该水提工艺设计合理,可为苓桂术甘颗粒的研制提供理论和试验基础。Objective To optimize the water extraction process for preparation of Linggui Zhugan Gran ules. Methods The orthogonal test was used to investigate the effects of water volume, extraction time, and extraction times on the extraction rates of cinnamaldehyde and glycyrrhizic acid and the yield of dry ex tract and to optimize the water extraction process. Results In the optimal process, extraction was performed 3 times （1 h each） using water （8 times）. Conclusion With multiple indices that are suitable for the complexity of Chinese herbal coml^ound, the orthogonal test can be used to accurately evaluate the wa- ter extraction process. This study provides a theoretical and experimental basis for the development of Linggui Zhugan Granules.

关 键 词：桂皮醛 甘草酸 苓桂术甘颗粒 正交试验 水提工艺 

分 类 号：R283[医药卫生—中药学]