N末端脑利钠肽前体对心力衰竭患者心功能的评价作用  

The clinical value of NT-ProBNP in evaluation the severity of heart failure

作　　者：檀从德[1] 徐晓东[2] 

机构地区：[1]安徽省青阳县人民医院内一科,242800 [2]池州市人民医院心血管内科

出　　处：《中国基层医药》2013年第15期2250-2251,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨N末端脑利钠肽前体（NT-ProBNP）评价心力衰竭患者心功能的价值.方法 选择心力衰竭患者94例,按照纽约心脏病协会心功能分级将其分为心功能Ⅰ、Ⅱ、Ⅲ、Ⅳ四个等级；选择同期住院心功能正常患者5例为对照组.检测受试者血浆NT-ProBNP水平,收集患者心脏彩超检查结果.结果 心力衰竭患者左心室舒张末期内径（LV）随血浆中NT-ProBNP水平的升高而升高.不同心功能组（NYHA分级）患者随着心力衰竭程度加重,血浆NT-ProBNP水平相应升高.NT-ProBNP与LV以及NYHA分级均具有相关性（r =0.453、0.538,均P＜0.01）.而LV与心功能NYHA分级亦具有相关性（r=0.322,P＜0.01）,但相关性较前两者稍低.结论 NT-ProBNP能较好地反映心力衰竭患者心室重构程度以及心力衰竭失代偿程度.Objective To explore the clinical value of N-terminal prosoma of B-type natriuretic peptide （NT-ProBNP） in assessing the heart function of the patients with chronic heart failure. Methods 94 inpatients diag- nosed as chronic heart failure were divided into 4 groups （ Ⅰ、Ⅱ、Ⅲ、Ⅳ ） according to the cardiac function of NYHA Functional Class（ NYHA-FC）, and 5 inpatients with normal cardic function were also selected as control group. The plasma NT-ProBNP was detected. The results of heart color ultrasound was collected. Results In patients with heart failure ,left ventricular end-diastolic dimension（LV） increased following the increase of plasma NT-ProBNP level. A- mong NYHA-FC groups, NT-ProBNP levels were different, which increased as the NYHA-FC upgrades. Spearman cor- relation analysis showed that NT-ProBNP had good correlation with both LV and NYHA-FC（ r = 0. 453, P 〈0. 01;r = 0. 538, P 〈 0. 01 ）. There was also good correlation between LV and NYHA-FC （ r = 0. 322, P 〈 0. 01 ） ; but the correla- tion was slightly lower than the previous. Conclusion NT-ProBNP can reflect the level of ventricular remodeling and the severity of the cardiac decompensation in chronic heart failure patients.

关 键 词：心力衰竭 N末端脑利钠肽前体 左室舒张末期内径 

分 类 号：R541.6[医药卫生—心血管疾病]