联合应用葡萄糖酸锌与丹参注射液对噪声所致大鼠免疫系统影响的保护作用  

Protective effect of Zinc and Salvia on the immune system caused by noise in rats

作　　者：薛来俊[1] 张大军[1] 晓开提·依不拉音[2] 王婷[3] 寿玺[4] 

机构地区：[1]新疆维吾尔自治区克拉玛依,克拉玛依市中心医院职业病科,834000 [2]新疆医科大学公共卫生学院劳动卫生与环境卫生教研室 [3]新疆医科大学图书馆 [4]新疆医科大学第一附属医院实验动物科学研究部

出　　处：《中国基层医药》2013年第15期2257-2259,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：新疆维吾尔自治区克拉玛依市科技基金项目（SK2011-46）

摘　　要：目的 观察葡萄糖酸锌口服液与丹参注射液单独及联合应用对噪声所致大鼠免疫球蛋白（IgG、IgM、IgA）及免疫分子（IL-2、IL-4）浓度影响的保护作用.方法 50只SD雌性大鼠随机分为对照组、噪声组、加葡萄糖酸锌噪声组（加锌组）、丹参注射液噪声组（加参组）、加葡萄糖酸锌口服液＋注射丹参液噪声组（联合组）各10只,除对照组未暴露噪声外,其余各组均连续暴露高频稳态噪声2周,比较噪声干预后各组大鼠血清免疫球蛋白（IgG、IgM、IgA）及免疫分子（IL-2、IL4）浓度差异,并进行统计推断.结果 对照组血清IgG、IgM、IL-2、IL-4浓度均显著高于噪声组（均P＜0.05）、加锌组（均P＜0.05）、加参组（均P＜0.05）,差异有统计学意义；各组血清IgA浓度与对照组差异均无统计学意义（均P＞0.05）.噪声组血清IgG、IgM、IL-2、IL-4浓度均显著低于对照组（均P ＜0.05）、联合组（均P＜0.05）,差异有统计学意义；噪声组血清IgG、IgM、IL-2浓度明显低于加锌组（均P＜0.05）；各组血清IgA浓度与噪声组差异无统计学意义（均P＞0.05）.结论 噪声可引起大鼠免疫力减低,葡萄糖酸锌口服液、丹参注射液对噪声所致大鼠免疫系统的影响有保护作用,且两者联合比单独作用保护效果更强.Objective To observe the protective effect of the zinc gluconate combined with Salvia injection on noise induced serum immunoglobulin（ IgG, IgM, IgA） and immune molecules （ IL-2, IL-4 ） in rats. Methods 50 female SD rats were randomly divided into control group, noise group, zinc gluconate noise group （plus zinc group ）, Salvia injection noise group （ plus Salvia group） and Zinc glueonate oral liquid and Salvia injection noise group（ com- bined group）, 10 rats in each group. Except the control group, rats in the other groups were continuously exposed to high frequency steady noise for two weeks. The concentrations of serum immunoglobulin（IgG,IgM,IgA） and immune molecules （ IL-2, IL-4） after the intervention of noise were compared. Results Serum levels of IgG, IgM, IL-2, IL-4 of the control group were significantly higher than the noise group （ all P 〈 0.05 ）, plus zinc group （ all P 〈 0.05 ）, plus Salvia group（ all P 〈0.05 ）, the differences were statistically significant. Serum level of IgA of each group was not statistically different compared with control group （ all P 〉 0.05 ）. Serum levels of IgG, IgM, IL-2, IL-4 in the noise group were significantly lower than those in the control group （ all P 〈 0.05 ）, combined group （ all P 〈 0.05 ）, the differences were statistically significant. Serum levels of IgG, IgM, IL-2 in plus zinc group were significantly higher than the noise group（ all P 〈 0.05 ）. Serum IgA concentration of each group showed no significant difference com- pared with noise group（ all P 〉 0.05 ）. Conclusion Zinc gluconate oral solution and Salvia injection have protective effect on immune system affected by noise in rats, the protective effect of combination of zinc gluconate oral solution and Salvia injection is stronger than the individual.

关 键 词：噪声 葡萄糖酸锌 丹参注射液 免疫球蛋白 免疫分子 

分 类 号：R135[医药卫生—劳动卫生]